调强放疗联合奈达铂治疗直肠癌术后复发  

Intensity Modulated Radiotherapy Combined with Nadaplatin for Local Recurrence of Rectal Cancer

作　　者：王青民[1] 于兰[1] 杨敬磊[1] 

机构地区：[1]青岛市肿瘤医院放疗科,山东青岛266042

出　　处：《肿瘤基础与临床》2016年第1期48-50,共3页journal of basic and clinical oncology

摘　　要：目的目的分析调强放疗联合奈达铂治疗直肠癌术后复发患者的近期疗效和毒副反应。方法将经病理学证实的56例直肠癌术后复发患者分为2组:观察组28例给予调强放疗联合奈达铂化疗;对照组28例仅给予调强放疗。结果观察组和对照组的有效率分别为89.3%%和64.2%,1 a生存率分别为64.2%和42.8%,3 a生存率为28.6%和7.1%(P<0.05)。2组胃肠道反应和血小板减少发生率比较差异有统计学意义(P<0.05)。结论调强放疗联合奈达铂治疗直肠癌术后复发的疗效好于单纯放调强疗,且毒副反应可耐受。Objective To investigate the efficacy and toxicities of intensity modulated radiotherapy combined with nadaplatin for local recurrence of rectal cancer. Methods Fifty-six patients with locally recurrence of rectal cancer were divided into 2 group： the observation group and the control group. The 28 patients in the observation group were given with radiotherapy combined with nedaplatin chemotherapy; the 28 patients in the control group received radiotherapy only. Results The effective rate of the observation group was 89. 3%,and was 64. 2% of the control group（ P 〈0. 05）. The 1-,3-year survival rate of the observation group were 64. 2% and 28. 6%; and were 42,8%and 7. 1% of the control group（ P 〈0. 05）. There was a significant difference in the gastrointestinal reaction and thrombocytopenia between the two groups（ P 〈0. 05）. Conclusion The efficacy of intensity modulated radiotherapy combined with nadaplatin is better than intensity modulated radiotherapy in the treatment of local recurrence of rectal cancer,and the toxicities can be tolerated.

关 键 词：直肠癌 复发 适形调强放疗 奈达铂 

分 类 号：R735.37[医药卫生—肿瘤] R730.58[医药卫生—临床医学]