小剂量米非司酮联合孕三烯酮治疗围绝经期子宫肌瘤的临床疗效观察  

Clinical efficacy of small doses of mifepristone in Gestrinone treatment of perimenopausal uterine fibroids

作　　者：胡利辉 陈梅莲 顾立芳 

机构地区：[1]广东省肇庆市高要区人民医院,肇庆526040

出　　处：《北方药学》2016年第3期30-31,共2页Journal of North Pharmacy

摘　　要：目的:探讨小剂量米非司酮联合孕三烯酮治疗围绝经期子宫肌瘤的疗效。方法:选取我院子宫肌瘤患者78例,随机分为观察组和对照组。对照组采用米非司酮治疗。在对照组基础上,观察组联合使用孕三烯酮胶囊治疗。观察治疗效果。结果:观察组总有效率为94.9%,治疗后子宫体积为(22.01±5.64)cm^3,肌瘤体积为(5.38±5.21)cm3~,雌激素为(11.01±9.21)pmol/L,孕激素为(1.12±1.08)pmol/L,均优于对照组,组间比较有显著差异(P<0.05)。结论:小剂量米非司酮联合孕三烯酮治疗围绝经期子宫肌瘤,能够提高临床治疗效果,保障患者的生活质量。Objective： To investigate the low-dose mifepristone in Gestrinone therapeutic effect perimenopausal uterine fibroids. Methods：hospital 78 patients with uterine fibroids were randomly divided into observation group and control group. The control group with mifepristone. In the control group,based on the joint use of the observation group Gestrinone Capsule. Observation of therapeutic effect.Results： The total effective rate was 94.9%,uterine volume after treatment（22.01±5.64）cm^3,fibroid volume（5.38±5.21）cm^3,estrogen is（11.01±9.21） pmol / L,progesterone is（1.12±1.08）pmol / L,were better than the control group,there are differences（P0.05）between comparison groups. Conclusion： Low dose mifepristone in Gestrinone treatment of perimenopausal uterine fibroids,can improve the clinical treatment,protect the quality of life of patients.

关 键 词：米非司酮 孕三烯酮 围绝经期 子宫肌瘤 临床疗效 

分 类 号：R737.33[医药卫生—肿瘤]