他汀类药物在肾脏疾病治疗中的应用进展  

Progress of the application of statins to kidney disease

作　　者：周洁[1] 景颖[1] 戴兵[1] 梅长林[1] 

机构地区：[1]第二军医大学附属长征医院肾内科解放军肾脏病研究所,上海200003

出　　处：《中国实用内科杂志》2016年第3期219-222,共4页Chinese Journal of Practical Internal Medicine

基　　金：国家自然科学基金(81370844);上海市浦江人才计划(12PJ1403300);第二军医大学优秀青年学者资助项目

摘　　要：他汀类药物是临床常用的调脂药物,对心血管保护作用明确,在预防和治疗肾脏疾病方面也逐渐得到共识。他汀类药物作用于肾脏疾病的机制既有其降脂作用,也有其非降脂作用参与。部分研究认为他汀类药物具有肾脏保护作用,可以降低蛋白尿、延缓肾小球滤过率(glomerular filtration rate,GFR)下降等,但是不同的临床研究结论仍存在争议。他汀类药物在肾脏疾病中的应用有广阔的前景。Statins,which are common lipid-lowering drugs, have definite protective effect on cardial vessels. Currently their beneficial role in the prevention and treatment of kidney disease has been gradually recognized. Statins can improve the prognosis of kidney disease through the lipid-lowering effect and non lipid-lowering effect. Several studies have demonstrated renoprotective effects of statins, such as reducing of proteinuria and slowing the decline of e GFR. However, results of clilnical studies are conflicting. Statins might have great prospects in kidney disease.

关 键 词：他汀类药物 肾脏保护 蛋白尿 估算肾小球滤过率 

分 类 号：R573.9[医药卫生—消化系统]