氟哌噻吨美利曲辛联合萨氏扩张术治疗食管吻合口狭窄的临床效果  

Efficacy of combined use of deanxit and dilation with Savary-Gilliard dilator for anastomotic stenosis of esophagus after esophagectomy

作　　者：韩雪晶[1] 庞训雷[1] 肖烨[1] 曲德伟[2] 

机构地区：[1]徐州医学院附属医院消化病科,江苏省221002 [2]徐州医学院解剖教研室

出　　处：《江苏医药》2016年第5期534-535,共2页Jiangsu Medical Journal

基　　金：江苏省肿瘤生物治疗重点实验室(ZL1207)

摘　　要：目的观察氟哌噻吨美利曲辛(deanxit)联合萨氏扩张术治疗食管吻合口良性狭窄的临床效果。方法食管-贲门癌术后吻合口良性狭窄患者46例,随机均分为两组:B组仅给予萨氏扩张器扩张;A组在扩张治疗的基础上加用氟哌噻吨美利曲辛口服,每天早、中各1片,至首次扩张术后3个月。随访3个月,比较两组的临床疗效。结果 A组患者吻合口狭窄扩张术的有效率高于B组(95.65%vs.73.91%)(P<0.01),扩张次数减少,术后胸骨后疼痛发生率降低(P<0.05)。结论氟哌噻吨美利曲辛能通过缓解患者的焦虑、抑郁状态,有效改善食管吻合口良性狭窄扩张术的治疗效果。Objective To observe the efficacy of combined use of deanxit and dilation with Savary-Gilliard dilator for anastomotic stenosis of the esophagus after esophagectomy.Methods Forty-six patients with benigne anastomotic stenosis following esophagectomy were equally assigned into two groups.The patients in group A were treated with esophageal dilation combined with oral deanxit twice per day for three months.The patients in group B were treated with esophageal dilation alone as the controls.The patients were followed up for three months and the efficacy were compared between two groups.Results The effectiveness rate of esophageal dilation was higher in group A than that in group B（95.65%vs.73.91%）（P〈0.01）.The times of dilation and the occurrence of postoperative retrosternal pain were less in group A than those in group B（P〈0.05）.Conclusion The efficacy of esophagealdilation can be improved by attenuating the anxiety and depression produced by oral deanxit in the patients with benigne anastomotic stenosis after esophagectomy.

关 键 词：食管吻合口狭窄 氟哌噻吨美利曲辛 萨氏扩张器 

分 类 号：R735[医药卫生—肿瘤]