Two novel resin glycosides isolated from Ipomoea cairica with α-glucosidase inhibitory activity  

作　　者：LI Jie-Hong PAN Jie-Tao YIN Yong-Qin 

机构地区：[1]Department of Traditional Chinese Medicinal Chemistry, Guangdong Pharmaceutical University

出　　处：《Chinese Journal of Natural Medicines》2016年第3期227-231,共5页中国天然药物（英文版）

基　　金：supported by Chinese National Natural Science Fund(No.81202885);the Natural Science Foundation of Guangdong province of China(No.2015A030313585)

摘　　要：In the present study, two new compounds from Ipomoea cairica were identified and demonstrated to have a-glucosidase inhibitory activity. They were isolated by column chromatography on silica gel and sephadex LH-20 and finally purified by prep-HPLC, with their structures being elucidated by spectroscopic methods, such as 1D- and 2D-NMR and HR-TOF-MS, and chemical methods. Compounds 1 and 2, named cairicoside A and cairicoside B, were evaluated for a-glucosidase inhibitory activity by the MTT method, with the ICs0 values being 25.3 ± 1.6 and 28.5± 3.3 μmol·L-1, respectively.In the present study, two new compounds from Ipomoea cairica were identified and demonstrated to have α-glucosidase inhibitory activity. They were isolated by column chromatography on silica gel and sephadex LH-20 and finally purified by prep-HPLC, with their structures being elucidated by spectroscopic methods, such as 1D- and 2D-NMR and HR-TOF-MS, and chemical methods. Compounds 1 and 2, named cairicoside A and cairicoside B, were evaluated for α-glucosidase inhibitory activity by the MTT method, with the IC_(50) values being 25.3 ± 1.6 and 28.5 ± 3.3 μmol·L^(-1), respectively.

关 键 词：Ipomoea cairica Resin glycoside Simonic acid A a-Glucosidase 

分 类 号：TQ925.5[轻工技术与工程—发酵工程] TQ457.29