草酸艾司西酞普兰和盐酸度洛西汀治疗抑郁症对照研究  

A comparative study of escitalopram and duloxetine in treatment of patients with depression

作　　者：刘文明[1] 何宏[1] 孙润珠[1] 陈云春[1] 谭庆荣[1] 

机构地区：[1]第四军医大学西京医院,陕西西安710032

出　　处：《精神医学杂志》2016年第1期1-3,共3页Journal of Psychiatry

基　　金：国家自然科学基金资助项目(编号:30870886;30700259)

摘　　要：目的探讨草酸艾司西酞普兰和盐酸度洛西汀治疗抑郁症的疗效和安全性。方法将70例抑郁症患者随机分为研究组和对照组(各35例),研究组应用草酸艾司西酞普兰系统治疗,对照组应用盐酸度洛西汀系统治疗,为期8周。在治疗前及治疗后第1、2、4、6、8周末采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)以及治疗中需处理的不良反应症状量表(TESS)评定疗效和不良反应。结果治疗后第8周末,两组疗效及总不良反应发生率比较差异无统计学意义(P>0.05)。两组HAMD评分在治疗后第1周末均较各自治疗前降低(P<0.05)。两组HAMD和HAMA评分在治疗后第2、4、6、8周末均低于治疗前(P<0.05)。在治疗后第6周末,对照组的HAMD和HAMA评分均低于研究组(P<0.05)。结论草酸艾司西酞普兰与盐酸度洛西汀对抑郁症患者均有较好的疗效。Objective To explore the efficacy and safety of escitalopram and duloxetine in treatment of patients with depression. Methods A total of 70 patients with depression were randomly divided into study group（ n = 35） with duloxetine and control group（ n = 35） with escitalopram for 8 weeks of treatment. They were assessed with Hamilton Depression Rating Scale（ HAMD）,Hamilton Anxiety Rating Scale（ HAMA） and Treatment Emergent Symptoms Scale（ TESS） at baseline,the 1^（st）,2^（nd）,4^（th）,6^（th）and 8^（th）weekend of treatment. Results There were no significant differences for effective rates and side effects rates between two groups at the 8^（th）weekend of treatment（ P〉0. 05）. The scores of HAMD in two groups at the 1^（st）weekend of treatment were all significantly lower than those at baseline（ P〈0. 05）. The scores of HAMD and HAMA in two groups at the2^（nd）,4^（th）,6^（th）and 8^（th）weekend of treatment were all significantly lower than those at baseline（ P〈0. 05）. At the 6^（th）weekend of treatment,the scores of HAMD and HAMA in control groups were all significantly lower than those in study group（ P〈0. 05）.Conclusion It＇s effective for escitalopram and duloxetine to treat the patients with depression.

关 键 词：抑郁症 草酸艾司西酞普兰 盐酸度洛西汀 

分 类 号：R749.4[医药卫生—神经病学与精神病学]