伴抑郁症状精神科急诊留观患者149例甲状腺激素水平研究  

Research of serum level of thyroid hormones in 149 patients with depressive symptoms in psychiatric emergency ward

作　　者：李颖[1] 潘轶竹[1] 马征[1] 朱辉[1] 

机构地区：[1]首都医科大学附属北京安定医院,北京市100088

出　　处：《精神医学杂志》2016年第1期23-25,共3页Journal of Psychiatry

摘　　要：目的探讨甲状腺激素水平与抑郁症和抑郁症状的相关性及临床意义。方法将149例伴有抑郁症状的急诊留观患者按照是否为抑郁症,分为抑郁症组(71例)和非抑郁症组(78例),测定其血清促甲状腺素(TSH)、三碘甲状腺原氨酸(TT3)、游离三碘甲状腺原氨酸(FT3)、甲状腺素(TT4)、游离甲状腺素(FT4)的水平。结果抑郁症组血清FT4、TT4水平低于非抑郁症组(P<0.05);男性与女性抑郁症组患者的FT4、TT4水平均低于各自非抑郁症组(P<0.05);抑郁症组HAMD总分与FT4水平呈正相关(P<0.05)。结论抑郁症的发病可能与甲状腺功能变化有关。FT4水平可能反映抑郁症患者的病情严重程度。Objective To explore the relationship of serum thyroid hormones level with major depressive disorder and depressive symptoms,as well as its clinical significance. Methods 149 patients in psychiatric emergency ward were divided into depression group（ n = 71） and non-depression group（ n = 78） and their serum levels of thyroid stimulating hormone（ TSH）,triiodothyronine（ TT3）,free triiodothyronine（ FT3）,thyroxin（ TT4）,free thyroxin（ FT4） were measured in both groups. Results Serum levels of FT4 and TT4 in depression group were significantly lower than those in non-depression group（ P〈0. 05）. Serum levels of FT4 and TT4 in males or females in depression group were significantly lower than those in corresponding non-depression group（ P〈0. 05）. Total score of HAMD in depression group was significantly positively correlated with serum level of FT4（ P〈0. 05）. Conclusion Abnormality of thyroid function may be related with the aetiology of depressive disorder. Serum level of FT4 may reflect the severity of depression.

关 键 词：抑郁症 抑郁症状 甲状腺激素 

分 类 号：R749.4[医药卫生—神经病学与精神病学]