Near-infrared light-activated cancer cell targeting and drug delivery with aptamer-modified nanostructures  

作　　者：Yu Yang Jingjing Liu Xiaoqi Sun Liangzhu Feng Wenwen Zhu Zhuang Liu Meiwan Chen 

机构地区：[1]State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macao, Avenida da Universidade, Taipa, Macao, China [2]Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou 215123, China

出　　处：《Nano Research》2016年第1期139-148,共10页纳米研究（英文版）

基　　金：This work was partially supported by the National Natural Science Foundation of China （Nos. 51222203 and 51132006）, the National Basic Research Program of China （Nos. 2011CB911002 and 2012CB932601）, a Jiangsu Natural Science Fund for Distinguished Young Scholars, the Macao Science and Technology Develop- ment Fund （No. 062/2013/A2） and the Research Fund of the University of Macao （Nos. MYRG2014-00033- ICMS-QRCM and MRGOO4/CMW/2014/ICMS）.

摘　　要：Stimuli-activated targeted delivery systems for highly accurate treatment of tumors have received considerable attention in recent years. Herein, we reveal a light-activable cancer-targeting strategy that uses a complementary DNA sequence to hybridize and mask sgc8 aptamers conjugated onto photothermal agents such as gold nanorods or single-walled carbon nanotubes （SWNTs）. Upon exposure to near-infrared （NIR） laser, localized photothermal heating of the surface of those nano-agents results in dehybridization of the double-stranded DNA and uncaging of the aptamer sequence to allow specific cancer-cell targeting. Utilizing doxorubicin-loaded SWNTs as a model system, targeted drug delivery to cancer cells activated by NIR light was achieved. This work demonstrates the concept of NIR-activable tumor-targeting delivery systems with controllable cancer-cell binding to potentially enable highly specific and efficient cancer therapy.Stimuli-activated targeted delivery systems for highly accurate treatment of tumors have received considerable attention in recent years. Herein, we reveal a light-activable cancer-targeting strategy that uses a complementary DNA sequence to hybridize and mask sgc8 aptamers conjugated onto photothermal agents such as gold nanorods or single-walled carbon nanotubes （SWNTs）. Upon exposure to near-infrared （NIR） laser, localized photothermal heating of the surface of those nano-agents results in dehybridization of the double-stranded DNA and uncaging of the aptamer sequence to allow specific cancer-cell targeting. Utilizing doxorubicin-loaded SWNTs as a model system, targeted drug delivery to cancer cells activated by NIR light was achieved. This work demonstrates the concept of NIR-activable tumor-targeting delivery systems with controllable cancer-cell binding to potentially enable highly specific and efficient cancer therapy.

关 键 词：near-infrared（NIR）-activable drug delivery APTAMER gold nanorods single-walled carbonnanotubes 

分 类 号：Q279[生物学—细胞生物学] TN304.18[电子电信—物理电子学]