KLF4在肿瘤中的最新研究进展  

Research progress of KLF4 in tumor

作　　者：刘海霞[1] 宋晖[1] 马芮[1] 李娜[1] 周福兴[1] 陈必良[1] 

机构地区：[1]第四军医大学西京医院妇产科,陕西西安710032

出　　处：《中国妇幼健康研究》2016年第2期282-284,共3页Chinese Journal of Woman and Child Health Research

基　　金：国家自然科学基金资助项目(编号:81301921);陕西省自然科学基金资助项目(编号:2013JM4023)

摘　　要：上皮锌指蛋白4(KLF4)是一个在多种组织中表达的锌指结构转录因子,包括肠上皮及皮肤组织,它在细胞变异及细胞周期停滞都发挥着重要作用。首先,根据靶基因功能,KLF4既可以激活也可以抑制转录作用;其次,在不同的细胞微环境中,KLF4既可以作为肿瘤抑制因子,也可以作为癌基因;再者,KLF4在重组已分化成纤维母细胞为类似胚胎干细胞的可诱导多能干细胞中发挥重要作用。该综述目的是总结KLF4的生物特性及其与肿瘤发生发展的分子机制最新进展。Kruppel-like factor 4 （KLF4）is a zinc finger-type transcription factor expressed in a variety of tissues, including epithelium of intestine and skin, which plays critical role in differentiation and cell cycle arrest. Firstly, KLF4 can both activate and repress transcription according to target gene. Moreover, KLF4 can be a tumor suppressor or an oncogene resting in different cellular context. Finally, KLF4 is important in reprogramming differentiated fibroblasts into inducible pluripotent stem cells, likely embryonic stem cells. The aim of this review was to summarize biological functions of KLF4 and the latest molecular mechanisms of tumor occurrence and development.

关 键 词：上皮锌指蛋白4 肿瘤 增殖 分化 上皮间质转化 

分 类 号：R733[医药卫生—肿瘤]