正电子发射断层扫描成像对帕金森病症状评估的研究进展  

Positron emission tomography study on Parkinson＇s disease symptom assessment

作　　者：刘美辰[1] 解敬慧[2] 浦兰兰 梁战华[1] 

机构地区：[1]大连医科大学附属第一医院神经内科,大连116011 [2]大连医科大学附属第一医院核医学科,大连116011

出　　处：《中华神经医学杂志》2016年第3期315-318,共4页Chinese Journal of Neuromedicine

摘　　要：PD的运动症状和非运动症状均存在复杂的神经病理学及神经生物学机制，借助正电子发射断层扫描成像（PET）技术可观察到PD上述两种症状的典型影像学表现，协助临床诊断。本文现就PET技术在PD中的应用综述如下。Parkinson＇s disease （PD）, one of the most common neurodegenerative diseases, is characterized by motor symptoms, like static tremor, rigidity, bradykinesia and postural balance disorder, and some non-motor symptoms such as cognitive impairment, sleep disturbance, depression, emotional problems. The pathogenesis of PD is related to the synthesis and metabolism of dopamine in the brain. In recent years, more and more studies have indicated that the non-dopaminergic nervous system plays an important role in the pathogenesis of PD. The EFNS and the MDS-ES refer that PET can assist the diagnosis of PD in clinical application, thus, PET provides powerful tools for PD. We reviewed the application for the progression of PET imaging in PD.

关 键 词：帕金森病 正电子发射断层扫描 运动症状 认知功能障碍 

分 类 号：R742.5[医药卫生—神经病学与精神病学]