环氧合酶-2表达与皮肤癌发生相关性的Meta分析  

A Meta-analysis on the relationship between COX-2 and skin cancer development

作　　者：刘明明[1] 朱玉洁[1] 王鑫[1] 李立群[1] 闻思思[1] 何楚怡 魏兰兰[1] 张凤民[1] 钟照华[1] 商庆龙[1] 

机构地区：[1]哈尔滨医科大学微生物学教研室,黑龙江哈尔滨150081

出　　处：《哈尔滨医科大学学报》2016年第1期85-89,共5页Journal of Harbin Medical University

基　　金：国家自然科学基金资助项目(81000726)

摘　　要：目的探讨环氧合酶-2（cyclooxygenase-2,COX-2）与皮肤癌（skin cancer）发生的关联性。方法以皮肤癌、COX-2等为检索词,检索维普数据库、CNKI数据库、万方学术期刊数据库和Pub Med英文数据库中相关文献,筛选后纳入相关病例对照研究文献进行Meta分析,通过Stata软件计算合并OR值及其95%的可信区间。结果入选研究共15项,累计皮肤鳞状细胞癌229例,基底细胞癌99例,对照组128例,数据表现为同质性。与对照组比较,COX-2表达与皮肤鳞状细胞癌的发生风险相关,合并OR为20.06（10.36~38.85）;与皮肤基底细胞癌发生风险相关,合并OR为12.30（4.69~32.26）。结论COX-2表达与皮肤癌的发生风险增加可能具有相关性。Objective To investigate the relationship between COX-2 and skin cancer development. Methods The published case-control studies which COX-2 expression was related skin cancer were searched in Wanfang,CNKI,CQVIP Chinese databank and Pubmed. Meta-analysis was applied to analyze the pooled odds ratio（ OR） and 95% confidence interval（ CI）. Results Fifteen studies which comprised 229 cases of squamous cell carcinoma and 99 cases of basal cell carcinoma of skin and 128 control persons were enrolled. Compared with controls,COX-2 expression significantly increased the development risk of skin squamous cell carcinoma by a pooled OR of 20. 06（ 95% CI = 10. 36 ~ 38. 85） and of skin basal cell carcinoma by a pooled OR of 12. 30（ 95% CI = 4. 69 ~ 32. 26）. This result was not influenced by pathological types in subgroup analysis. Conclusion COX-2 expression may have relationship with the increased risk of skin cancer development.

关 键 词：皮肤癌 环氧合酶-2 META分析 

分 类 号：R739.5[医药卫生—肿瘤]