Wnt/β-catenin通路在动脉粥样硬化发生发展中的作用  

Role of Wnt/β-catenin signaling pathway in atherosclerosis

作　　者：马守原[1] 姚树桐[2] 朱平[1] 秦树存[2] 

机构地区：[1]中国人民解放军总医院南楼心血管内科,北京100853 [2]泰山医学院动脉粥样硬化研究所山东省高校动脉粥样硬化重点实验室,山东泰安271000

出　　处：《中国病理生理杂志》2016年第3期564-568,共5页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.81370381;No.91539114;No.81570410);山东省泰山学者岗专项基金资助项目(No.200811)

摘　　要：动脉粥样硬化（atherosclerosis,AS）作为心血管疾病（cardiovascular disease,CVD）的主要病理基础,严重危害人们的健康~[1]。AS是多因素、多发病环节参与的慢性炎症性疾病,内皮损伤和功能减退是其发生的启动环节,炎症细胞浸润和炎症介质释放、氧化应激反应、血管平滑肌细胞增殖以及泡沫细胞形成和死亡是AS发生发展的关键机制。Atherosclerosis is a multifactorial process associated with endothelial cell injury and dysfunction,inflammation,oxidative stress,cell proliferation,angiogenesis and so on,all of which play a crucial role in atherosclerosis.Wnt/β-catenin signaling pathway is highly conservative in the development of body,abnormal activation of which is related to types of diseases including cancer.Accumulating studies have shown that Wnt/β-catenin signaling pathway is involved in inflammation,oxidative stress and so on.This article would make a review about the role of Wnt/β-catenin signaling pathway in atherosclerosis based on the pathogenic mechanisms underlying atherosclerosis as mentioned above.

关 键 词：WNT/Β-CATENIN信号通路 动脉粥样硬化 

分 类 号：R363[医药卫生—病理学]