自噬及其在神经退行性疾病中的作用  

Mechanism of autophagy and its role in neurodegenerative diseases

作　　者：张敬美[1,2] 刘海青[3] 白波[4] 

机构地区：[1]济宁医学院行为医学教育研究所,济宁272067 [2]山东师范大学生命科学学院,济南250014 [3]泰山医学院基础医学院,泰安271000 [4]济宁医学院神经生物学研究所,济宁272067

出　　处：《济宁医学院学报》2016年第1期58-63,共6页Journal of Jining Medical University

基　　金：山东省科技发展计划(2012GGA08100);济宁医学院校级科研计划项目(JY2013RW001)

摘　　要：自噬是细胞内降解聚集或错误折叠蛋白质及异常细胞器的一个过程。作为一个细胞基础代谢过程,自噬对于维持细胞的稳态和物质能量的再循环有着重要作用。神经元自噬调节的异常会伴随异常蛋白质的聚集和沉积,导致神经元稳态失衡和神经退行性改变。近新研究显示,自噬调节异常与广泛的神经退行性疾病中有关,如阿尔茨海默病、帕金森病、亨廷顿舞蹈症、肌肉萎缩性侧索硬化症等有密切联系。本文重点对自噬机制及其与神经退行性疾病的最新进展进行综述。Autophagy is a bulk degradation process of aggregated and aberrant proteins as well as dysfunctional organells. As a basic metabolism process,autophagy is crucial for maintaining homeostasis and recycling the materials and energy. The dysfunctional regulating of autophagy is usually accompanied with the accumulation of aggregated proteins which is associated with several neurodegenerative diseases such as Alzheimer＇s disease,Parkinson ＇s disease,Huntington ＇s disease,amyotrophic lateral sclerosis etc. In this reviews,we focus on the advanced findings concerning the mechanism of autophagy and the involvement of autophagy in neurodegenerative diseases.

关 键 词：自噬 神经退行性疾病 阿尔茨海默病 帕金森病 亨廷顿舞蹈症 

分 类 号：R741.02[医药卫生—神经病学与精神病学]