脑电超慢涨落图检查对预测癫痫药物控制敏感性的价值  

The Predictive Value of Encephalofluctuographic of Super Slow Checks on Drugs to Control Epilepsy Susceptibility

作　　者：杨小军 

机构地区：[1]陕西省汉中市复退军人精神病康复医院,陕西汉中723000

出　　处：《河北医学》2016年第3期448-450,共3页Hebei Medicine

基　　金：陕西省卫生厅科研基金;(编号:2012D13)

摘　　要：目的:探讨脑电超慢涨落图检查对预测癫痫药物控制敏感性的临床价值。方法:选择患者80例,根据治疗效果分为两组,各40例,对所有患者均进行脑电超慢涨落图检查,比较两组5-羟色胺(5-HT)、乙酰胆碱(Ach)、去甲肾上腺素(NE)、γ-氨基丁酸(GABA)、谷氨酸(Glu)水平。并了解脑功能指数中的运动指数、兴奋抑制指数、血管舒缩指数变化情况。结果:敏感组运动指数、兴奋抑制指数及血管舒缩指数均显著低于不敏感组(P<0.05),敏感组兴奋性神经递质中的5-HT、Glu和Ach水平均显著低于不敏感组(P<0.05),抑制性神经递质NE及GABA显著高于不敏感组(P<0.05)。结论:采用脑电超慢涨落图分析,如果测定到中枢神经系统中兴奋性递质水平升高而抑制性神经递质水平降低,则预示患者对该药物治疗不敏感,而治疗后,兴奋性递质水平降低而抑制性神经递质水平升高,则提示患者对该治疗方案敏感,可以考虑继续应用。Objective： To investigate the predictive value of encephalofluctuographic of super slow checks on drugs to control epilepsy susceptibility. Method： 80 cases with epilepsy were divided into two groups with40 cases in each group. All patients were received EEG super slow fluctuation test. The level of 5-HT,Ach,NE,GABA,Glu of two groups were compared. And the changes of the motion index,excitement and inhibition index,vasomotor index of two groups were also compared. Result： The motion index,excitment and inhibiton index,vasomotor index of sensitive group were lower than non-sestitive grup（ P〈0. 05）. The level of excitatory neurotransmitter such as 5-HT,Glu,Ach of sensitive group were lower than non-sensitive grup（ P〈0. 05）. The level of inhibition neurotrans mitter such as NE,GABA of sesitive group were higher than non-sensitive group（ P〈0. 05）. Conclusion： With EEG superslow fluctuation chart analysis,the result.

关 键 词：脑电超慢涨落图 癫痫 预测 药物敏感性 

分 类 号：R742.1[医药卫生—神经病学与精神病学]