头孢噻肟酸合成工艺的研究  

Research on Synthesis Process of Cefotaxime Acid

作　　者：孙津鸽 高得瀛 李文杰 李志军 刘红坤 

机构地区：[1]河南康达制药有限公司,河南周口466200

出　　处：《广东化工》2016年第6期87-88,共2页Guangdong Chemical Industry

摘　　要：为了改进头孢噻肟酸合成工艺,文章以三乙胺为催化剂,在抗氧剂存在的下,7-ACA与AE-活性酯(MEAM)在混合溶剂中反应制得头孢噻肟酸。结果制得头孢噻肟钠的含量稳定在99%以上,且目标产物经核磁共振和IR确认结构。改进后的工艺提高了含量,降低了色级,降低了成本,具有更高的经济效益和市场竞争力。In order to improve the synthesis process of Cefotaxime acid, Make Cefotaxime acid by 7-ACA and MEAM under the catalysis of triethylamine esterification and the antioxidant in the mixed solvent. The content of the prepared Cefotaxime acid is more than 99 %. The structure of adefovir dipivoxil was confirmed by ~1H-NMR and IR. The research enhanced receiving content and reduced the cost and the color grade. So it has higher profit and market competitive power.

关 键 词：头孢噻肟酸 合成 工艺改进 

分 类 号：R914.5[医药卫生—药物化学]