门冬氨酸鸟氨酸联合纳洛酮治疗肝性脑病的临床效果  

L-ornithine-L-aspartate Combine Naloxone Treat Hepatic Encephalopathy Clinical Effect

作　　者：席智文[1] 

机构地区：[1]河南省商丘市第一人民医院消化内科,河南商丘476100

出　　处：《中国医药指南》2016年第8期17-18,共2页Guide of China Medicine

摘　　要：目的探讨门冬氨酸鸟氨酸联合纳洛酮治疗肝性脑病的临床效果。方法将100例肝性脑病患者随机分为观察组和对照组。对照组采用常规综合治疗,观察组患者在此基础上应用纳洛酮联合门冬氨酸鸟氨酸治疗,观察2组的疗效。结果对照组有l6例在24 h内神志清醒,20例在48 h内神志明显改善,血氨水平下降,14例无明显改善;观察组有28例24 h内神志恢复,17例在48 h内神志改善,血氨水平下降,5例无明显改善。观察组的疗效显著优于对照组(P<0.05)。结论门冬氨酸鸟氨酸联合纳洛酮治疗肝性脑病可以有效改善患者临床症状,临床效果显著。Objective To investigate the clinical effect of L-ornithine-L-aspartate combined with naloxone in the treatment of hepatic encephalopathy. Methods 100 cases of patients with hepatic encephalopathy were randomly divided into observation group and control group. Patients in control group were treated with routine treatment, naloxone combined with aspartic acid ornithine treatment observation group on the basis of this; observe the curative effect of the two groups. Results In the control group, 16 cases of conscious within 24 h, 20 cases within 48 h was significantly improved and blood ammonia levels were decreased, 14 cases had no obvious improvement. In the observation group, there were 28 cases within 24 h recovery of consciousness, 17 cases improve consciousness within 48 h, the blood ammonia levels were decreased, 5 cases without significantly improved. The efficacy of the observation group was significantly better than that in the treatment group（P 〈0.05）. Conclusion L-ornithine-L-aspartate combined with naloxone in the treatment of hepatic encephalopathy can effectively improve the clinical symptoms of the patients, the clinical effect is significant.

关 键 词：纳洛酮 门冬氨酸鸟氨酸 肝性脑病 

分 类 号：R575.5[医药卫生—消化系统]