应用个体化3D模型分析肾动脉狭窄与肾动脉弯曲程度的相关性  

Correlative Study of Renal Artery Stenosis and Bend Using Patient-specific 3D Models

作　　者：曹海明[1] 王洪阳[1] 邓荣海[1] 邓素雄[1] 王长希[1] 费继光[1] 

机构地区：[1]中山大学附属第一医院泌尿肾移植病区,广东广州510080

出　　处：《中山大学学报（医学科学版）》2016年第1期61-65,共5页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：国家自然科学基金资助项目(81270836)

摘　　要：【目的】建立患者个体化肾动脉3D几何模型,研究肾动脉弯曲程度与肾动脉狭窄的关系。【方法】临床收集15例单侧肾动脉狭窄病例,狭窄侧肾动脉及对侧非狭窄肾动脉的计算机断层扫描血管造影(CTA)数据,共30支肾动脉,其中15支狭窄肾动脉,15支非狭窄肾动脉。采用曲率与迂曲度参数来反映动脉的弯曲程度,使用MIMICS 16.0建立患者个体化肾动脉3D模型,并测得肾动脉主干的最大曲率,弯曲度与长度,分为狭窄组与非狭窄组,进行同一个体的两侧肾动脉解剖学参数配对比较。【结果】建立了患者个体化肾动脉3D模型,在单侧肾动脉狭窄的病例中,狭窄组肾动脉最大曲率(cur1)与非狭窄组肾动脉最大曲率(cur2)之间的差异有统计学意义(P<0.01);狭窄组肾动脉主干迂曲度(tor1)与非狭窄组肾动脉主干迂曲度(tor2)之间的差异有统计学意义(P<0.01);狭窄组肾动脉主干起点至最大曲率处的距离(len1)与狭窄组肾动脉主干起点到狭窄动脉最狭窄处的距离(len3)之间有相关性(相关系数为0.7);狭窄肾动脉主干起点至最大曲率处的距离(len1)与非狭窄肾动脉主干起点至最大曲率处的距离(len2)之间没有统计学差异(P>0.05)。【结论】肾动脉狭窄与肾动脉弯曲有相关性。对同一患者,肾动脉狭窄倾向发生于动脉弯曲度大的肾动脉。对于具体的患者及时发现狭窄位置与进展,对未来预测血管疾病显示出潜在的价值。【Objective】 To establish patient-specific renal arterial 3D models. To explore the relationship of renal artery stenosis and bend. 【Methods】 A total of 15 patients with diagnosed unilateral renal arterial stenosis in our hospital underwent CT angiography.Among them, we visualized 15 stenotic renal arteries and 15 non-stenotic renal arteries. Patient-specific renal arterial 3D models are established by MIMICS 16.0 software. The curvatures and lengths of main renal arteries were measured by mimics 16.0 software. Thirty renal arteries were divided into two groups（15 stenotic renal arteries and 15 non-stenotic renal arteries）. 【Results】 Patient-specific renal arterial 3D models were established successfully. Significant difference（P〈0.01） was shown between the max curvatures of stenotic renal arterial group（cur1） and the max curvatures of non-stenotic renal arterial group（cur2）.The length between the max curvature and the origin of main renal artery in stenotic renal arterial group was len1.Similarly,the length in non-stenotic renal arterial group was len2. The length between the max degree of stenosis and the origin of main renal artery in stenotic renal arterial group was len3. Significant difference（P〈0.01） was shown between the tortuosity of main renal artery（tor1） and the tortuosity of main renal artery（tor2）. High intraclass correlation coefficient（value 0.7） was shown between len1 and len3. No significant difference（P〈0.05） was shown between len1 and len2. 【Conclusion】 Renal artery stenosis and bend shows positive correlation.Artery stenosis probably occurs in the higher bending renal artery. Determination of stenosis location and progression in time for a specific patient show a potential benefit for future prediction of this vascular disease. The understanding and the prediction of the evolution of stenosis are major tasks for the medical community.

关 键 词：肾动脉狭窄 肾动脉弯曲程度 三维建模 曲率 

分 类 号：R691.9[医药卫生—泌尿科学]