LIM矿化蛋白1在牙髓干细胞和骨髓间充质干细胞中的研究进展  

Research progress of the role of LIM mineralization protein-1 in dental pulp stem cells and bone marrow mesenchymal stem cells

作　　者：费腾[1] 胡伟平[1] 袁梦桐[1] 

机构地区：[1]哈尔滨医科大学附属第二医院口腔修复科,黑龙江哈尔滨150086

出　　处：《口腔医学》2016年第3期285-288,共4页Stomatology

摘　　要：LIM矿化蛋白1(LMP-1)是一种胞内信号转导分子,体内外研究表明它在成骨细胞分化过程中起到促进骨形成的重要作用。目前认为LMP-1是通过刺激某些诱导骨形成的因子如骨形态发生蛋白(BMP)的合成及分泌发挥作用,从而提高骨形态发生蛋白及其他成骨因子的成骨活性。该文围绕LMP-1的作用及在牙髓干细胞和骨髓间充质干细胞矿化方面的研究现状作一综述。The LIM mineralization protein-1（ LMP-1） is a kind of intracellular signal transduction molecule which plays an important role in facilitating bone formation during the process of osteoblast differentiation according to both in vivo and in vitro studies. So far,it has been believed that LMP-1 functions by stimulating the synthesis and secretion of certain factors like bone morphogenetic protein（ BMP） which can induce bone formation,thus improving the osteogenic activity of BMP and other osteogenic factors. This article reviewed the role of LMP-1 and the research progress concerning the mineralization of dental pulp stem cells（ DPSC） and bone marrow stromal cells（ BMSC）.

关 键 词：LIM矿化蛋白1 骨形态发生蛋白 牙髓干细胞 骨髓间充质干细胞 

分 类 号：R780.2[医药卫生—口腔医学]