抗高血压药引起药疹的文献分析  

Antihypertensive agent-induced drug eruptions：a literature review

作　　者：苏惠春[1] 姚煦[1] 王宝玺[1] 

机构地区：[1]中国医学科学院 北京协和医学院 皮肤病研究所过敏与风湿免疫科,南京210042

出　　处：《中华皮肤科杂志》2016年第3期219-222,共4页Chinese Journal of Dermatology

摘　　要：抗高血压药种类繁多，结构复杂，常用的有利尿剂、钙离子拮抗剂、血管紧张素转化酶抑制剂、血管紧张素Ⅱ受体阻滞剂、β受体阻滞剂5大类，可引起各种不同类型的药疹。通过文献回顾，对抗高血压药引起的血管性水肿、红斑狼疮样、银屑病样、湿疹样、疱疹样、扁平苔藓样等药疹的临床特征、发病机制、治疗及转归进行归纳总结，实现抗高血压药引起药疹的早发现、早诊断、早停药、早治疗，并为抗高血压药引起的药疹的临床和基础研究提供信息和思路。There are various kinds of antihypertensive agents with complex chemical structures. Common antihypertensive agents are divided into 5 classes, including diuretics, calcium antagonists, angiotensin-converting enzyme inhibitors, angiotensin Ⅱ receptor blockers and β-blockers, and can cause various types of drug eruptions. This review summarizes clinical characteristics, possible pathogenesis, treatment and consequences of antihypertensive agent-induced drug eruptions, including angioedema, and lupus erythematosus-like, psoriasis-like, eczematoid, herpetiform or lichen planus-like drug eruptions, in hope to facilitate their early detection, diagnosis and treatment, and to provide information and ideas for clinical and basic researches into them.

关 键 词：药疹 抗高血压药 血管性水肿 湿疹 银屑病 天疱疮 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]