Manipulating extrinsic and intrinsic obstacles to axonal regeneration after spinal cord injury  

作　　者：Eugene Mironets Di Wu Veronica J.Tom 

机构地区：[1]Department of Neurobiology and Anatomy, Drexel University College of Medicine

出　　处：《Neural Regeneration Research》2016年第2期224-225,共2页中国神经再生研究（英文版）

基　　金：funded by NIH R01 NS085426(VJT);the Craig H.Neilsen Foundation(DW)

摘　　要：Spinal cord injury（SCI）is a traumatic event that can lead to permanent motor and sensory deficits.After the initial trauma,axons of surviving neurons rapidly retract.While there may be a small degree of abortive sprouting,virtually all attempts at robust regrowth across the lesion site ultimately fail.Thus,neurons below the level of the injury are permanently disconnected from their normal input,resulting in persistent loss of function.Spinal cord injury（SCI）is a traumatic event that can lead to permanent motor and sensory deficits.After the initial trauma,axons of surviving neurons rapidly retract.While there may be a small degree of abortive sprouting,virtually all attempts at robust regrowth across the lesion site ultimately fail.Thus,neurons below the level of the injury are permanently disconnected from their normal input,resulting in persistent loss of function.

关 键 词：RHEB Manipulating extrinsic and intrinsic obstacles to axonal regeneration after spinal cord injury 

分 类 号：R651.2[医药卫生—外科学]