非小细胞肺癌EGFR、pEGFR蛋白表达水平及临床意义分析  

Expression level of EGFR and p EGFR protein in non small cell lung cancer and analysis of its clinical significance

作　　者：李振华[1] 陈志龙[2] 高山[1] 

机构地区：[1]武汉市中心医院呼吸内科,武汉430000 [2]广州军区武汉总医院药剂科

出　　处：《西南国防医药》2016年第3期264-267,共4页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的观察非小细胞肺癌（NSCLC）表皮生长因子受体（EGFR）及磷酸化表皮生长因子受体（p EGFR）蛋白表达水平变化及其临床意义。方法选择本院2014年6月~2015年7月收治的NSCLC患者43例,均经手术治疗,术中留取NSCLC组织及癌旁正常肺组织各43份,均经免疫组化法测定EGFR、p EGFR蛋白水平,并分析比较不同年龄、性别、临床分期等与EGFR、p EGFR蛋白水平的关联性。结果 NSCLC组织EGFR、p EGFR蛋白表达阳性分别为27例（62.8%）、15例（34.9%）,均显著高于癌旁正常组织的2例（4.7%）、1例（2.3%）（P〈0.05）。肿瘤分化程度及TNM分期与EGFR表达呈正相关（P〈0.05）;患者吸烟史、病理学类型、分化程度、TNM分期与p EGFR表达具有密切关联（P〈0.05）。结论 NSCLC的EGFR、p EGFR蛋白表达水平显著升高,且其表达水平与肺癌分化程度及TNM分期均有密切关联,临床应重视。Objective To observe the expression level changes of epidemal growth factor receptor（EGFR） and phosphorylation epidemal growth factor receptor（p EGFR） protein in non small cell lung cancer（NSCLC） and its clinical significance. Methods 43 patients with NSCLC treated in our hospital between June 2014 and July 2015 were selected and received the operative treatment. 43 pieces of NSCLC tissues and normal para-carcinoma tissues were obtained in the operation. Immunohistochemical method was carried out to detect EGFR and p EGFR protein levels. Analysis was made in the correlation of different ages, gender, and clinical stage with EGFR and p EGFR protein levels. Results There were 27 cases（62.8%） and 15 cases（34.9%） of positive EGFR and p EGFR protein expression in NSCLC tissues. The numbers were significantly higher than those of cases in normal para-carcinoma tissues [2 cases（4.7%） and 1（2.3%）]（P 〈 0.05）. There was a positive correlation between the degree of tumor differentiation and TNM staging and EGFR expression（P 〈 0.05）. The factors of smoking history, pathological type, differentiation degree, and TNM staging were closely related to p EGFR expression（P 〈 0.05）. Conclusion The expression levels of p EGFR and EGFR in non small cell lung cancer significantly increase, and the expression levels are closely related to the degree of lung cancer differentiation and TNM staging of lung cancer.

关 键 词：非小细胞肺癌 表皮生长因子受体 磷酸化表皮生长因子受体 相关性 

分 类 号：R734.2[医药卫生—肿瘤]