肺癌与肺部感染患者凝血指标及血清炎性因子的相关性研究  

Correlation between coagulation parameters and serum inflammatory factors of lung cancer and pulmonary infection patients

作　　者：施益挺[1] 何立峰[1] 华钢[1] 徐震[1] 宋旭[1] 

机构地区：[1]宁波市第二医院胸外科,浙江宁波315016

出　　处：《中华医院感染学杂志》2016年第6期1306-1308,共3页Chinese Journal of Nosocomiology

基　　金：浙江省科技厅研究基金资助项目(036890-21)

摘　　要：目的探讨肺癌与肺部感染患者凝血指标及血清炎性因子的相关性研究,为肺癌及其肺部感染患者的临床治疗提供理论依据。方法选择2012年3月-2015年8月医院接诊的肺癌或肺部感染患者104例进行研究,根据病理结果分为肺部感染组56例和肺癌组48例,选取同期55名健康体检人员为对照组,对比分析3组受试人员的凝血指标和血清炎性因子水平。结果肺部感染组和肺癌组患者血浆凝血酶原时间、活化部分凝血活酶时间、D-二聚体、血纤蛋白原及白细胞、单核细胞指标均显著高于对照组;肺部感染组和肺癌组患者血小板体积分布宽度与平均血小板体积指标均显著低于对照组,以上指标差异均有统计学意义(P<0.05);对照组白介素-6与肿瘤坏死因子水平均显著低于肺部感染组和肺癌组,其差异有统计学意义(P<0.05);3组受试人员中白介素-6水平与单核细胞呈线性正相关,IL-6水平与凝血酶原时间呈线性负相关。结论肺癌和肺部感染患者均存在凝血功能紊乱与炎症反应,并且其血清炎症因子与凝血指标之间具有相关性。OBJECTIVE To explore the correlation between coagulation parameters and serum inflammatory factors of the lung cancer and pulmonary infection patients so as to provide theoretical bases for clinical treatment of the patients with lung cancer and pulmonary infections.METHODS A total of 104 patients with lung cancer and pulmonary infections who were treated in the hospital from Mar 2012 to Aug 2015 were enrolled in the study and divided into the pulmonary infection group with 56 cases and the lung cancer group with 48 cases according to the pathological findings,meanwhile,55 healthy people who underwent the physical examination were chosen as the control group.The coagulation parameters and levels of serum inflammatory factors were observed and compared among the three groups of participants.RESULTS The prothrombin time,activated partial thromboplastin time,D-dimer,fibrinogen,white blood cells,and monocytes were significantly higher in the pulmonary infection group and the lung cancer group than in the control group.The platelet volume distribution width and mean platelet volume were significantly lower in the pulmonary infection group and the lung cancer group than in the control group（P0.05）.The levels of interleukin-6and tumor necrosis factor of the control group were significantly lower than those of the pulmonary infection group and the lung cancer group（P0.05）.The interleukin-6level of the three groups of participants showed linear positive correlation with the monocytes,while the IL-6level showed linear negative correlation with the prothrombin time.CONCLUSIONThe patients with lung cancer and pulmonary infections have coagulopathy and inflammations,and the serum inflammatory factors are associated with the coagulation parameters.

关 键 词：肺癌 肺部感染 凝血指标 血清炎性因子 

分 类 号：R734.2[医药卫生—肿瘤]