老年急性脑梗死患者感染病原菌分布与对内皮素和脑钠肽水平的调查研究  

Distribution of pathogens causing infections in elderly patients with acute cerebral infarction and impact on levels of serum endothelin and brain natriuretic peptide

作　　者：徐华峰[1] 刘宏[1] 邓俊义[1] 金毅[1] 陈义鹏[1] 陈华[1] 

机构地区：[1]丽水市人民医院急诊科,浙江丽水323000

出　　处：《中华医院感染学杂志》2016年第6期1333-1335,共3页Chinese Journal of Nosocomiology

基　　金：浙江省医药卫生科技计划基金资助项目(2012KYB213)

摘　　要：目的分析老年急性脑梗死患者感染病原菌分布,并研究其对内皮素和脑钠肽(BNP)水平的影响,为临床相关治疗提供借鉴。方法对2010年3月-2014年8月医院诊治的80例老年急性脑梗死感染患者为感染组,同期选取老年急性脑梗死未感染患者100例为未感染组,健康体检者100名为对照组,分析病原菌分布及3组受试人员的临床指标,数据采用SPSS 19.0。结果感染组80例患者共分离出病原菌80株,以革兰阴性菌为主,共46株占57.5%;与对照组和未感染组相比,感染组患者血清中内皮素及肿瘤坏死因子α(TNFα)、转化生长因子β(TGFβ)、成纤维细胞生长因子(bFGF)、白细胞介素6-(IL-6)和白细胞介素-10(IL-10)水平明显高于其他两组,差异有统计学意义(P<0.01)。结论老年急性脑梗死患者容易受到病原菌感染,病原菌以革兰阴性菌为主,且感染引起患者血清中内皮素水平升高,BNP蛋白水平明显降低。OBJECTIVE To investigate the distribution of pathogens causing infections in elderly patients with acute cerebral infarction and observe the influence on levels of endothelin and brain natriuretic peptide（BNP）so as to provide guidance for clinical treatment.METHODS A total of 82 elderly patients with acute cerebral infarction complicated with infections who were treated in the hospital from Mar 2010 to Aug 2014 were assigned as the infection group,meanwhile,100 elderly acute cerebral infarction patients without infections were set as the non-infection group,and 100 healthy people who underwent the physical examination were chosen as the control group.The distribution of pathogens and clinical indicators were observed and compared among the three groups of participants,and the statistical analysis of data was performed with the use of SPSS 19.0software.RESULTS Totally 80 strains of pathogens were isolated from 80 patients in the infection group,of which 57.5%（46strains）were gram-negative bacteria.The levels of serum endothelin,tumor necrosis factorα（TNFα）,transforming growth factorβ（TGFβ）,fibroblast growth factor（bFGF）,interleukin-6（IL-6）,and interleukin-10（IL-10）were significantly higher in the infection group than in other two groups（P0.01）.CONCLUSION The elderly patients with acute cerebral infarction tend to be infected with pathogens,the gram-negative bacteria are dominant among the pathogens,and the infections may lead to the elevated level of serum endothelin and the remarkable reduction of level of BNP.

关 键 词：急性脑梗死 病原菌 脑钠肽 内皮素 

分 类 号：R743.33[医药卫生—神经病学与精神病学]