血清糖链抗原（125、19-9）、血管内皮生长因子 C水平与卵巢癌淋巴结转移的关系  

Analysis of serum carbohydrate antigen （125,19-9）,vascular endothelial growth factor C in detecting ovarian cancer lymph node metastasis

作　　者：胡娟[1] 赵长新[1] 李永明[2] 李宗婷[2] 胡春霞[3] 蒋华[3] 

机构地区：[1]连云港市第二人民医院检验科,江苏省连云港222002 [2]连云港市第二人民医院妇科,江苏省连云港222002 [3]连云港市第二人民医院肿瘤科,江苏省连云港222002

出　　处：《中国基层医药》2016年第4期485-489,共5页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：探讨血清糖链抗原（CA125、CA199）、血管内皮生长因子 C（VEGF-C）检测对卵巢癌腹膜后淋巴结转移早期诊断的临床价值，为卵巢癌腹膜后淋巴结转移提供血清学预测指标。方法选择卵巢癌行腹膜后淋巴结清扫术患者51例为观察组，其中卵巢癌腹膜后淋巴结转移23例；另选择卵巢良性肿瘤32例为对照组。采用电化学发光法检测血清 CA125、CA199水平，采用酶联免疫吸附测定法（ELISA）检测血清VEGF-C 水平。结果卵巢癌患者血清 CA125水平为（1682．5±261．5）u／mL，明显高于对照组的（30．5±6．3）u／mL（P ＜0．01）；卵巢癌患者血清 VEGF-C 水平为（2125．6±96．7）pg／mL，明显高于对照组的（1738．0±79．8）pg／mL（P ＜0．01）；51例卵巢上皮癌患者初诊时血清 CA199水平为（72．5±30．6）u／mL，对照组血清 CA199水平为（17．4±8．5）u／mL，腹膜后淋巴结转移 CA199水平为（134．9±72．5）u／mL，卵巢癌腹膜后淋巴结转移组血清 CAl99水平较无淋巴结转移组、对照组明显升高（t ＝7．39、18．34，均 P ＜0．01）。血清VEGF-C ＋CA199＋CA125检测对卵巢癌腹膜后淋巴转移的诊断灵敏度、特异度、准确率分别为95．5％、96．5％、99．5％。结论血清 CA125、VEFG-C、CA199水平联合检测对预测卵巢癌腹膜后淋巴结转移有重要临床价值。Objective To investigate the clinical value of serum carbohydrate antigen （CA125,CA199）and vascular endothelial growth factor C （VEGF-C）in early diagnosis of ovarian carcinoma.Methods 51 cases of ovarian cancer patients with retroperitoneal lymph node dissection were performed in the observation group,including 23 cases of ovarian cancer retroperitoneal lymph node metastasis,32 cases of ovarian benign tumor were selected as the control group.The serum levels of CA199 and CA125 were detected by the method of chemiluminescence detection,and the serum VEGF-C level was detected by enzyme-linked immunosorbent assay （ELISA）.Results The serum level of CA125 in patients with ovarian cancer （1 682.5 ±261.5）u/mL was significantly higher than that in the control group （30.5 ±6.3）u/mL（P 〈0.01）,serum VEGF-C level in ovarian cancer patients （2 125.6 ±96.7）pg/mL was signif-icantly higher than that in the control group （1 738.0 ±79.8）pg/mL （P 〈0.01 ）.The serum CA199 level of 51 patients with newly diagnosed epithelial ovarian cancer was （72.5 ±30.6）u/mL,serum CA199 level of the control group was （17.4 ±8.5）u/mL,CA199 level of retroperitoneal lymph node metastasis was （134.9 ±72.5）u/mL, ovarian cancer retroperitoneal lymph node metastasis CAl99 serum level were significantly higher than those without lymph node metastasis and the control group （t =7.39,18.34,all P 〈0.01）.The diagnostic sensitivity,specificity and accuracy of serum VEGF-C ＋CA199 ＋CA125 in detection of ovarian cancer retroperitoneal lymph node metasta-sis were 95.5%,96.5%,99.5%.Conclusion Combined detection of CA125,VEFG-C and CA199 in serum has important clinical value in predicting lymph node metastasis of ovarian cancer.

关 键 词：糖链抗原 血管内皮生长因子C 肿瘤转移 淋巴 卵巢肿瘤 

分 类 号：R737.31[医药卫生—肿瘤]