灯盏花素对急性脑梗死患者血清NSE、Ang-2、IL-6的影响及其疗效  

Effect of breviscapine on serum NSE,Ang-2 and IL-6 levels and its efficacy in patients with acute cerebral infarction

作　　者：马进[1] 余能伟[2] 任智文[1] 陈岷[1] 武航海[1] 

机构地区：[1]四川省人民医院药剂科,四川成都610072 [2]四川省人民医院神经内科,四川成都610072

出　　处：《中国生化药物杂志》2015年第11期110-112,115,共4页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的观察灯盏花素治疗急性脑梗死患者的疗效及对血神经元特异性烯醇化酶（neuron specific enolase,NSE）、血管紧张素-2（angiotensin-2,Ang-2）、白介素-6（interleukin-6,IL-6）的影响研究。方法选取2014年1月~2015年1月四川省人民医院神经内科收治的60例急性脑梗死（acute cerebral infarction,ACI）患者,随机分成2组,每组30例。2组患者均给予西药常规治疗,治疗组加用灯盏花素治疗,疗程为2周。比较2组治疗前后神经功能缺损程度评分及疗效,酶联免疫吸附法（ELISA）测定血清NSE、Ang-2、IL-6的水平。结果观察组治疗后神经缺损程度评分显著低于对照组（P〈0.05）。观察组总有效为27例（90.00%）,显著高于对照组的20例（66.67%）（χ2=4.81,P〈0.05）。观察组治疗后血清Ang-2、IL-6和NSE水平显著低于对照组（P〈0.05）。结论灯盏花素治疗急性脑梗死疗效显著,能改善脑部微循环、保护脑组织,其作用机制可能是通过降低血清NSE、IL-6和Ang-2水平实现。Objective To observe the efficacy of breviscapine in the treatment of patients with acute cerebral infarction and its effect on serum neuron specific enolase（ NSE）,angiotensin-2（ Ang-2） and interleukin-6（ IL-6） levels. Methods 60 cases of acute cerebral infarction（ ACI） patients from January 2014 to January 2015 in Sichuan Provincial People＇s Hospital were selected and randomly divided into two groups,30 cases in each group.All patients were given conventional western medicine treatment,and the observation group were also treated with breviscapine. After 2 weeks,the degree of neural function defect scores and efficacy were compared and the serum levels of NSE,Ang-2 and IL-6 were detected by enzyme linked immunosorbent assay（ ELISA） and compared pre-and post- treatment between two groups. Results The degree of neural function defect score posttreatment in observation group was significantly lower than that in control group（ P〈0. 05）. The overall response in observation group was 27 cases（ 90. 00%）,which was significantly higher than 20 cases（ 66. 67%） in control group（ χ2= 4. 81,P〈0. 05）. The serum levels of Ang-2,IL-6 and NSE post-treatment in observation group were significantly lower than those in control group（ P〈0. 05）. Conclusion The curative effect of breviscapine in treatment of acute cerebral infarction is significantly,which could improve the cerebral microcirculation,protect the brain tissue,and its mechanism may be through reducing the serum levels of NSE,IL-6 and Ang-2.

关 键 词：急性脑梗死 灯盏花素 神经元特异性烯醇化酶 血管紧张素-2 白介素-6 

分 类 号：R743.3[医药卫生—神经病学与精神病学]