胃癌中循环肿瘤细胞与临床特征的关系  

A Preliminary Study on the Relationship between Circulating Tumor Cells Count and Clinical Features in Patients with Gastric Cancer

作　　者：郭迎雪[1] 李贵新[1] 李方超[1] 李新新[1] 李敖[1] 

机构地区：[1]潍坊医学院肿瘤学教研室,山东潍坊261053

出　　处：《潍坊医学院学报》2016年第1期73-75,共3页Acta Academiae Medicinae Weifang

摘　　要：目的探讨胃癌中循环肿瘤细胞循环肿瘤细胞(CTC)计数与临床特征、分期及肿瘤标志物的关系。方法选取胃癌患者80例、慢性胃炎患者50例、健康志愿者50例,治疗前抽取外周血7.5ml用Cell Search方法计数静脉血中CTC数目,分析其与患者性别、年龄、临床分期及肿瘤标志物的关系。结果胃癌患者CTC计数显著高于慢性胃炎患者和健康人(P<0.01);胃癌患者外周血中CTC数目与患者的性别、年龄无明显关系(P>0.05),但随着肿瘤临床分期递进而增加(P<0.05)。外周血CTC计数与CEA,CA199水平无明显相关性(P>0.05),与血清CA724水平成正相关(P<0.05)。结论胃癌外周血CTC计数与患者临床特征有一定相关性,可初步反映疾病状态,并有望成为早期诊断胃癌的新的血液学指标。Objective To investigate the level of circulating tumor cells（ CTC） in peripheral blood of gastric cancer and its correlation with clinical features and stage,and tumor markers in gastric cancer. Methods Totally 80 patients with gastric cancer were selected for study,50 patients with chronic gastritis and 50 normal volunteers were selected as the control groups. The CTC expression of peripheral blood was detected by Cellsearch system before treated,and its relationship with the age,sex,clinical stage and tumor marker was analyzed. Results CTC count in gastric cancer patients was significantly higher than that in chronic gastritis patients and healthy controls（ P〈0. 01）. CTC count in gastric cancer patients was rarely related to the sex,age（ P〈0. 05） and was closely related to clinical stage（ P〈0. 05）. CTC counting had no obvious correlation with CEA,CA199（ P〉0. 05））,and had positive correlation with CA724（ P〈0.05）. Conclusion CTC counting in gastric cancer patients has a certain correlation with clinical characteristics,can preliminarily reflect the patient＇s disease states,and is expected to become a new hematology index to improve the early diagnosis of gastric cancer.

关 键 词：胃肿瘤 循环肿瘤细胞 肿瘤标志物 

分 类 号：R735.2[医药卫生—肿瘤]