肺癌患者呼出气一氧化氮数值变化的临床意义  

Clinical significance of fractional exhaled nitric oxide in lung cancer patients

作　　者：刘鹏飞[1] 赵大辉[1] 张杜超[1] 肖坤[1] 解立新[1] 

机构地区：[1]解放军总医院呼吸科,北京100853

出　　处：《解放军医学院学报》2016年第2期101-104,共4页Academic Journal of Chinese PLA Medical School

基　　金：海南省自然科学基金项目(814330);中央保健课题(W2013BJ11)~~

摘　　要：目的探索肺癌患者呼出气一氧化氮(exhaled nitric oxide,e NO)的数值变化及意义。方法回顾性分析2012年12月-2014年12月在我院确诊的164例肺癌患者的临床资料及呼出气一氧化氮和肺功能的检测结果,另外选取172例健康人作为对照。结果肺癌患者的呼出气一氧化氮平均值为33.85 ppb,明显高于健康人的呼出气一氧化氮平均值16.80 ppb(P<0.05)。FEV1%≥80%的肺癌患者呼出气一氧化氮平均值为32.50 ppb,明显低于FEV1%<80%患者的43.54 ppb(P<0.05)。164例中鳞癌、腺癌、小细胞癌、类癌、其他类型分别占18.90%、68.90%、3.66%、6.71%、1.83%,前4组的呼出气一氧化氮值分别为39.85 ppb、32.94 ppb、38.95 ppb、24.48 ppb,4组间差异有统计学意义(P<0.01)。结论肺癌患者呼出气一氧化氮高于正常水平且以鳞癌和小细胞肺癌尤为明显,因此开展呼出气一氧化氮检测对肺癌的分类诊断有提示意义。Objective To investigate the clinical significance of fractional exhaled nitric oxide in lung cancer patients. Methods Clinical data, exhaled nitric oxide（e NO） measurements and pulmonary function test results of 164 patients with lung cancer by pathological diagnosis in our hospital from December 2012 to December 2014 were retrospectively analyzed. Another 172 healthy people were served as control group. Results The average exhaled nitric oxide level of patients with lung cancer was 33.85 ppb, while it was 16.80 ppb in normal control group, which showed significant differences（P〈0.05）. In the lung cancer group, patients with FEV1%≥80% had lower average exhaled nitric oxide level than patients with FEV1%80% with significant differences（32.50 ppb vs 43.54 ppb, P〈0.05）. Of the 164 cases, squamous cell carcinoma, adenocarcinoma, small-cell lung cancer, lung carcinoid tumor, and others accounted for 18.90%, 68.90%, 3.66%, 6.71% and 1.83%, respectively. The e NO levels in squamous cell carcinoma group, adenocarcinoma group, small-cell lung cancer group and lung carcinoid tumor group were 39.85 ppb, 32.94 ppb, 38.95 ppb, 24.48 ppb, respectively, which showed significant differences（P〈0.01）. Conclusion The e NO levels in patients with lung cancer are higher than the normal level, especially in patients with squamous cell carcinoma and small-cell lung cancer. The measurement of e NO will be helpful in the diagnosis and classification of lung cancer.

关 键 词：呼出气一氧化氮 肺癌 气道炎症反应 

分 类 号：R734.2[医药卫生—肿瘤]