后颅窝减压术治疗Chiari畸形Ⅰ型合并脑积水疗效的Meta分析  

Posterion fossa decompression for Chiari I malformation with hydrocephalus: a meta-analysis

作　　者：张家康[1] 彭飞[1] 陈鑫[1] 侯旭[1] 张大明[1] 刘震东[1] 赵世光[1] 

机构地区：[1]哈尔滨医科大学附属第一医院神经外科,哈尔滨150001

出　　处：《中国临床神经外科杂志》2016年第3期158-160,共3页Chinese Journal of Clinical Neurosurgery

基　　金：十二五国家科技支撑计划(2013BAH06F04)

摘　　要：目的评价后颅窝减压术（PFD）治疗合并脑积水的Chiari畸形Ⅰ型的有效性。方法计算机检索EBSCO、Pub Med、Em Base、OVID等英文数据库以及中国知网、维普、万方等中文数据库,检索从建库到2015年5月31日发表的文献。采用STATA 13.0软件进行Meta分析。结果共纳入3篇文献,86例,PFD治疗83例;PFD术后好转率为82.3%（95%CI 74.2%～90.4%）;合并脑积水的Chiari畸形Ⅰ型中,女性占62.9%（95%CI 52.6%～73.1%）。结论合并脑积水的Chiari畸形Ⅰ型中,女性占大多数;PFD治疗合并脑积水的Chiari畸形Ⅰ型具有较高的有效率。Objective To evaluate the effect of posterior fossa decompression（PFD） on Chiari Ⅰ malformation associated with hydrocephalus.Methods The data which accorded with the demands of the present study were individually extracted the Chinese and English literature obtained by searching electronic database including EBSCO, PUBMED, EMBASE, CNKI, VIP, Wanfang and OVID from the day when the library was built to 31 May 2015. All the statistical analyses were performed by the STATA software version 13.Results The rate of improvement of Chiari I malformation associated with hydrocephalus was 82.3%（95% CI 74.2%～90.4%）. The female patients account for 62.9%（95%CI 52.6%～73.1%）of all the patients with Chiari I malformation associated with hydrocephalus.ConclusionThe female patients account for the majority of all the patients with Chiari malformation associated with hydrocephalus, and PFD is an effective method to treat this disease.

关 键 词：Chiari畸形Ⅰ型 脑积水 后颅窝减压术 疗效 META分析 

分 类 号：R742.82[医药卫生—神经病学与精神病学] R651.11[医药卫生—临床医学]