清肺祛瘀汤预防食管癌同步放化疗致放射性肺炎的疗效观察  

Effect of Qingfei Quyu Decoction in Prevention of Radiation Pneumonitis Induced by Concurrent Chemoradiotherapy for Esophageal Carcinoma Patients

作　　者：崔珍[1] 柳雯[2] 殷红梅[1] 李多杰[1] 刘静景[1] 沈学明[1] 彭开桂[1] 江浩[1] 

机构地区：[1]蚌埠医学院第一附属医院肿瘤放疗科,安徽233004 [2]蚌埠医学院第一附属医院中医科,安徽233004

出　　处：《中国中西医结合杂志》2016年第3期317-321,共5页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：安徽省"十二五"临床医学重点专科建设基金(No.01Z33);安徽省教育厅科研基金资助项目(No.KJ2015B075by);蚌埠医学院自然科学基金资助项目(No.Byky1342)

摘　　要：目的通过观察清肺祛瘀汤对食管癌同步放化疗患者的影响,评价清肺祛瘀汤预防放射性肺炎的效果。方法将120例中晚期食管癌患者随机分为治疗组(60例)和对照组(60例),两组均采用同步放化疗,治疗组在对照组基础上加用清肺祛瘀汤(1剂/日,共服用8周)。比较两组放射性肺炎发生率;计算近期临床获益率、卡氏评分(Karnofsky performance scale,KPS)改善有效率及体重改善有效率;比较两组1、2年生存率。结果治疗组与对照组放射性肺炎发生率分别为8.93%(15/56)和18.64%(11/59),两组比较差异有统计学意义(P<0.05);治疗组和对照组近期临床获益率分别为92.86%(52/56)和69.49%(41/59),两组比较差异有统计学意义(P<0.05),且治疗组KPS评分及体重改善有效率[89.29%(50/56)及83.05%(49/59)]较对照组高[80.36%(45/56)及66.10%(39/59)](P<0.05);两组的1、2年生存率分别为66.07%、35.71%和61.02%、30.51%,两组比较,差异无统计学意义(P>0.05)。结论食管癌同步放化疗中应用清肺祛瘀汤可以降低放射性肺炎的发生率并减轻放射性肺损害的程度,提高临床获益率并可改善患者生活质量。Objective To assess the effect of Qingfei Quyu Decoction（ QQD） in preventing radiation pneumonitis in esophageal carcinoma patients by concurrent using it with chemoradiotherapy. Methods A total of 120 patients with mid-late stage esophageal carcinoma were randomly assigned to the treatment group（ 60 cases） and the control group（ 60 cases）. All patients received concurrent radiochemotherapy. Patients in the treatment group additionally took QQD,one dose per day for 8successive weeks. The incidence of radiation pneunonitis was compared between the two groups. The improvement rates of short-term benefit rate,Karnofsky performance scale（ KPS）,and body weight（ BW） improvement rate were calculated between the two groups. The 1-and 2-year overall survival rates were compared between the two groups. Results The incidence of radiation pneunonitis was 8. 93%（ 15 / 56） in the treatment group and 18. 64%（ 11 / 59） in the control group（P 〈0. 05）. The short-term benefit rate was 92. 86%（ 52 / 56） in the treatment group and 69. 49%（ 41 / 59） in the control group（P 〈0. 05）.Besides,the KPS and BW improvement rate were higher in the treatment group [89. 29%（ 50 /56） and 83. 05%（ 49 /59） ]than in the control group [80. 36%（ 45 /56） and 66. 10%（ 39 / 59） ]（P〈 0. 05）. The 1-and 2-year overall survival rate were 66. 07% and 35. 71% in the treatment group,higher than those of the control group（ 61. 02% and 30. 51%; P 〉0. 05）. Conclusion Concurrent using QQD with chemoradiotherapy for treating esophageal carcinoma patients could lower the incidence of radiation pneumonitis,attenuate the degree of radiation induced lung injury,improve clinical benefit rate,and elevate their QOL.

关 键 词：食管癌 同步放化疗 放射性肺炎 中医药 清肺祛瘀汤 预防 

分 类 号：R735.1[医药卫生—肿瘤]