恶性肿瘤患者食欲素A水平变化及其与营养相关性研究  

Changes in Orexin A levels in patients with malignant tumor and its correlation with nutritional status

作　　者：刘兵兵[1] 杜红珍[1] 李增宁[1] 宋新霞[1,2] 郭婷[1,2] 石汉平[3] 

机构地区：[1]河北医科大学第一医院营养科,河北石家庄050031 [2]邢台市人民医院肿瘤内科,河北邢台054001 [3]中国医科大学航空总医院普外科中国科学院北京转化医学研究院,北京100012

出　　处：《中华肿瘤防治杂志》2016年第2期101-104,共4页Chinese Journal of Cancer Prevention and Treatment

基　　金：国家自然科学基金(81373046);河北省高层次人才资助项目(A201400542)

摘　　要：目的食欲素A（Orexin A）能明显抑制前列腺癌、结肠癌和胃癌等恶性肿瘤细胞的增殖,并诱导其凋亡,Orexin在恶性肿瘤中的变化及其意义报道较少。本研究探讨肺癌、胃癌和结/直肠癌患者血清Orexin A水平变化及其与常见营养指标的相关性。方法收集邢台市人民医院肿瘤内科2014-06-01-2014-12-31住院的93例恶性肿瘤患者（其中肺癌39例,胃癌29例,结/直肠癌25例）为研究对象,同时选取同期河北医科大学第一医院查体中心51名健康志愿者为对照。检测其血清Orexin A、总蛋白、白蛋白、血红蛋白、血糖、三头肌皮褶厚度（TSF）和体质指数（BMI）。血清Orexin A水平运用酶联免疫法测定,并分析恶性肿瘤患者血清Orexin A水平与上述各指标之间的相关性。结果恶性肿瘤患者血清Orexin A水平（11.31±4.60）ng/L,高于健康志愿者的（3.36±0.84）ng/L,z=-19.164,P〈0.001;老年患者（≥65岁）血清Orexin A水平显著低于非老年患者（〈65岁）,z=-5.899,P〈0.001;女性血清Orexin A水平高于男性,t=7.422,P=0.007;低体质量（BMI〈18.5）、正常体质量（18.5≤BMI≤23.9）和超重肥胖（BMI≥24.0）3组血清Orexin A水平相比,差异有统计学意义,χ2=61.111,P〈0.001。按年龄进行分层分析结果显示,≤50岁组、51～60岁组和61～70岁组的肺癌、胃癌、结/直肠癌患者和健康志愿者血清Orexin A水平相比,差异均有统计学意义,P〈0.001;3组肺癌患者血清Orexin A水平均为最高,结/直肠癌患者其次,健康志愿者最低。〉70岁组,肺癌、胃癌、结/直肠癌患者和健康志愿者血清Orexin A水平相比,差异有统计学意义,P〈0.001;其中肺癌患者血清Orexin A水平最高,胃癌患者其次,健康志愿者最低。恶性肿瘤患者血清Orexin A水平与白蛋白、血红蛋白、血糖和TSF呈负相关,P〈0.001;而与总蛋白之间无相关性,P〉0.05。结论恶性肿瘤患者血清Orexin A水平高于健康志愿者;恶性�OBJECTIVE Orexins A can obviously inhibit prostate cancer,colon cancer,gastric cancer and other malignant tumor cell proliferation and induce apoptosis.So far there are few studies related to the change and significance of orexins in malignant tumors.This study aims to explore the relativity between common nutritive index and the serum level of Orexin A in patients with lung cancer,colorectal cancer and gastric cancer.METHODS Totally 93 malignant tumor patients were recruited from Xingtai People＇s Hospital,including 39 cases of lung cancer,29 cases of gastric cancer and25 cases of colon and rectal cancer.At the same time,51 healthy volunteers were recruited from the first Hospital of Hebei Medical University as control.The serum level of Orexin A,total protein,albumin,hemoglobin,blood glucose,TSF and BMI in patients and volunteers were measured.The serum Orexin A levels were measured by ELISA,and the correlation between serum Orexin A level and each nutritive index was analyzed.RESULTS The serum Orexin A level in patients with malignant tumor was（11.31±4.60）ng/L higher than those in healthy volunteers（3.36±0.84）ng/L（z=-19.164,P〈0.001）.The serum Orexin A level was significantly lower in elderly patients（aged over 65）than that in non elderly patients（aged below 65）（z=-5.899,P〈0.001）.The serum Orexin A level in female was higher than that in male（t=7.422,P=0.007）.According to the BMI,the subjects were divided into low weight group（BMI18.5）,normal weight group（18.5≤BMI≤23.9）and overweight as well as obesity group（BMI≥24.0）,the serum Orexin A levels in three groups were statistically significant（χ2=61.111,P〈0.001）.The Serum Orexin A level was negatively correlated with serum albumin,hemoglobin,blood glucose and TSF in patients with malignant tumor（P〈0.001）,but there was no significant correlation with total protein（P=0.187）.CONCLUSIONS The serum Orexin A level in patients with malignant tumor is higher than that in normal volunteers.In patients wit

关 键 词：恶性肿瘤 营养状况 食欲素A 相关性 

分 类 号：R730.5[医药卫生—肿瘤]