脾多肽对胆囊癌化疗患者细胞免疫功能的影响  

Effect of lienal polypeptide injection on cellular immunity of patients with gallbladder cancer during chemotherapy

作　　者：吴武军[1] 于咏田 李晖[1] 刘晓刚 胡海田[1] 

机构地区：[1]陕西省人民医院肝胆外科,陕西西安710068

出　　处：《现代肿瘤医学》2016年第9期1404-1406,共3页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:81000940);陕西省科学发展研究项目(编号:2011kjxx-26)

摘　　要：目的:探讨脾多肽对接受胆囊癌辅助化疗患者细胞免疫功能的影响。方法:30例胆囊癌辅助化疗患者分为治疗组(化疗+脾多肽)和对照组(单纯化疗),采用流式细胞术检测淋巴细胞亚群变化。结果:化疗2周期后,治疗组CD4^+T、CD8^+T细胞占淋巴细胞总数分别为(53.73±10.24)%和(18.29±5.81)%,显著高于同期对照组的(31.81±10.19)%和(10.23±5.96)%(P<0.05)。同时,治疗组CD4+T细胞比例较术前的(43.51±7.30)%有明显升高(P<0.05)。治疗组和对照组之间NK细胞比例差别无统计学意义(P>0.05),两组间化疗毒副作用相似(P>0.05)。结论:脾多肽可提高胆囊辅助化疗患者外周血CD4^+T、CD8^+T细胞比例,改善免疫功能。Objective：To investigate the effects of lienal polypeptide injection on cellular immunity of gallbladder cancer patients during chemotherapy. Methods ： All 30 cases of gallbladder cancer were divided into two groups ： thera- py group（ chemotherapy ＋ lienal polypeptide） and control group （chemotherapy）. The lymphocyte subsets variations were calibrated in each group via flow cytometry. Results：After two cycles of chemotherapy, the percentages of CD4 ＋ T, CD8 ＋ T cells in therapy group were much higher than those in control group （53.73 ± 10.24） % vs （31.81± 10.19） % ,P 〈 0.05 ; （ 18.29 ± 5.81 ） % vs （ 10.23 ± 5.96） %, P 〈 0.05. Simultaneously, in therapy group, the percentage of CD4 ＋ T cell was significantly raised after treatment（43.51 ±7.30） % vs （53.73 ± 10.24） % ,P 〈0.05）. No difference was observed on percentage of NK cell and side effects of chemotherapy between wo groups （ P 〉 0.05 ）. Conclusion ： Lienal polypeptide injection can improve immune by promoting the percentages of CD4 ＋ T, CD8 ＋ T cells.

关 键 词：脾多肽 胆囊癌 化疗 细胞免疫 

分 类 号：R735.8[医药卫生—肿瘤]