近红外染料在宫颈癌早期诊断中的应用  

Application of near infrared dye in early diagnosis of cervical tumor

作　　者：段利利[1] 王林[1] 吝蓓蕾 陈必良[1] 郭倩[1] 孙哲[1] 张娟梅[1] 吕静[1] 

机构地区：[1]第四军医大学西京医院妇产科,陕西西安710032

出　　处：《现代肿瘤医学》2016年第9期1430-1432,共3页Journal of Modern Oncology

基　　金：国家自然科学基金项目(编号:81172459)

摘　　要：目的:探讨近红外荧光染料在宫颈癌早期临床诊断中的应用价值。方法:选取我院2013年4月-2015年4月期间内收治的宫颈疾病患者100例,对其临床病理资料和早期诊断结果进行回顾性分析,以病理学诊断为金标准,对比分析近红外荧光染料吲哚菁绿(ICG)和阴道镜这两种检查方式对宫颈上皮内瘤样病变(CIN)、宫颈癌及炎症的检测符合率。结果:经病理学检查证实,所有宫颈疾病患者中早期宫颈癌患者30例,其中腺癌4例、鳞状细胞癌26例,CIN 20例,其中CIN I级4例、CIN II级7例、CIN III级6例、原位癌3例,宫颈炎症50例;ICG检查对早期宫颈瘤、CIN、宫颈炎症的诊断符合率分别为100%、95%、96%,均高于阴道镜。二者的综合诊断符合率比较,差异具有统计学意义(P<0.05)。结论:应用近红外染料荧光学检测对宫颈疾病患者进行诊断,可以提高早期宫颈癌及癌前病变的诊断准确率,具有较好的应用前景。Objective：To investigate the value of near infi＇ared fluorescent dyes in the early clinical diagnosis of cervical cancer. Methods：All 100 patients with cervical diseases in our hospital were selected fi＇om April 2013 to April 2015. Retrospective analysis of the clinical pathologic data and early diagnosis results of all patients was performed. The gold standard was diagnosed by pathology. Comparative analysis of the near infi＇ared fluorescent dye indocyanine green（ICG） and colposcopy both examination of cervical intraepithelial neoplasia（ CIN）, cervical cancer and inflammation of the coincidence rate of detection was tients, early cervical cancer was detected in 30 cases made. Results：Pathological examination confirmed that in all pa- , include 4 cases of adenocarcinoma, squamous cell carcinoma 26 cases. CIN 20 cases, including CIN I grade 4 cases, II grade 7 cases, III grade 6 cases, in situ cancer 3 cases, and cervical inflammation 50 cases. The diagnostic accuracy of ICG in cervical neoplasia,CIN and cervicitis were 100% , 95% and 96% ,which were higher than the results of vaginal vaginal examination, the comprehensive diagnostic accuracy of the two were compared, the difference was statistically significant（P 〈 0.05）. Conclusion： Diagnosis of cervical diseases by using near infrared dye fluorescence detection can improve the accuracy of diagnosis of early cervical neoplasia and precancerous lesions. It has good application prospect.

关 键 词：近红外染料 吲哚菁绿 宫颈癌 早期诊断 

分 类 号：R737.33[医药卫生—肿瘤]