淋巴瘤单发骨病变的^(18)F-FDG PET/CT影像学分析  

^(18)F- FDG PET/ CT imaging analysis of lymphoma with solitary bone marrow invasion lesion

作　　者：刘婧慧[1] 李丽琴[1] 王争明[1] 李德鹏[1] 马爱菊[1] 

机构地区：[1]中国人民解放军火箭军总医院核医学科,北京100088

出　　处：《现代肿瘤医学》2016年第9期1452-1457,共6页Journal of Modern Oncology

摘　　要：目的:研究原发性骨淋巴瘤与单发继发性淋巴瘤骨髓浸润的^(18)F-FDG PET/CT影像学表现,探讨^(18)F-FDG PET/CT对原发性骨淋巴瘤的诊断及鉴别诊断价值。方法:回顾性分析经病理证实的25例单发骨淋巴瘤的^(18)F-FDG PET/CT影像学资料。结果:25例骨淋巴瘤均为单发,其中14例位于脊柱骨,10例位于附肢骨,1例位于肋骨。15例为原发性骨淋巴瘤,10例为继发性淋巴瘤骨髓浸润。原发性骨淋巴瘤15例中非霍奇金淋巴瘤11例,霍奇金淋巴瘤4例;继发性淋巴瘤骨髓浸润10例中非霍奇金淋巴瘤7例,霍奇金淋巴瘤3例。25例骨淋巴瘤中23例CT表现为骨质密度异常改变,2例病变骨质密度未见明显异常改变。病变FDG摄取不同程度增高,SUV_(max)范围为2.6~24.5。原发性骨淋巴瘤及继发性淋巴瘤骨髓浸润病变SUV_(_(max))经Mann-Whitney U检验提示原发性骨淋巴瘤与继发性淋巴瘤骨髓浸润病变SUV_(max)有差异(P=0.007)。结论:原发性骨淋巴瘤^(18)F-FDG PET/CT影像学表现有一定的特征性,分析其表现对原发性和继发性骨淋巴瘤的诊断及鉴别诊断有一定的临床价值。Objective： To study the ^18F - fluorodeoxyglucose （ ^18F - FDG） PET/CT imaging of primary lymphoma of bone and single bone marrow invasion of secondary lymphoma, and to investigate the value of ^18 F - FDG PET/CT in the diagnosis and differential diagnosis of primary lymphoma of bone. Methods：PET/CT findings of 25 patients with pathology proven solitary bone lymphoma were retrospectively analyzed. Results：All 25 cases of bone lymphoma were solitary bone invasion lesion. 14 cases were located in the vertebral column, 10 cases in the attached bone, and 1 case in the costal bone. 15 cases were primary lymphoma of bone, and 10 cases were secondary affection. 15 cases of primary lymphoma of bone include 11 cases of non - Hodgking lymphoma and 4 cases of Hodgking lymphoma. 10 cases of secondary lymphoma include 7 cases of non - Hodgking lymphoma,3 cases of Hodgking lymphoma. CT imagines of 23 cases of bone lymphoma showed abnormal bone density, and 2 cases had no obvious abnormal changes in bone density. 25 lesions all showed increased FDG uptake, and the range of maximal standard uptake value （ SUV ） was 2.6 24.5. Mann - Whitney U test demonstrated that there was statistical difference in SUV of primapy lymphoma of bone and secondary lymphoma bone marrow invasion （P = 0. 007）. Conclusion： ^18F - FDG PET/CT imaging features of pri- mary lymphoma of bone are characteristic, analysis of its performance in the diagnosis and differential diagnosis of primary and secondary bone lymphoma has a certain clinical value.

关 键 词：淋巴瘤 骨 脱氧葡萄糖 正电子发射断层显像术 体层摄影术 发射型计算机 

分 类 号：R733[医药卫生—肿瘤]