年轻人与中老年人的胃癌特征及预后情况的比较  

Comparative the characteristics of young people and the elderly and prognosis of gastric cancer cases

作　　者：刘洪涛[1] 蔡相军[1] 王克夫[1] 初侃[1] 刘亮[1] 钟枢哲 侯铁伟 熊仁青[1] 

机构地区：[1]解放军第202医院普通外科,辽宁沈阳110812

出　　处：《现代肿瘤医学》2016年第10期1602-1607,共6页Journal of Modern Oncology

基　　金：辽宁省科学技术计划项目(编号:2011225021)

摘　　要：目的:比较不同年龄段胃癌患者的特征和预后。方法:收集418名胃癌患者,病理确诊为原发性胃腺癌。其中有29名年轻患者[≤40岁,年轻组(YG)]和389名中老年患者[>40岁,年长组(OG)]。分析人口统计学和临床病理特征的差异。结果:相对于中老年组,在年轻病人组中,女性患者的比例较高。5年总体生存YG组比OG组要显著降低。然而,接受根治性切除手术后,YG组与OG组5年生存率没有显著性差异;年轻组显示女性患者生存率明显低于男性患者。肿瘤类型、侵入深度、腹膜转移、远处转移和根治性切除治疗是独立的预后因素。结论:早期发现,早期诊断,积极行根治性切除是提高年轻人胃癌治疗水平及预后的关键,尤其是在女性患者中。Objective： Compared the clinicopathological features and the prognosis of gastric cancer patients in different ages. Methods ： A total of 418 patients with pathologically confirmed primary gastric adenocarcinoma were col- lected. There were 29 young[ ≤40 years of age,younger group （YG）] and 389 middle -aged [ 〉 40 years of age, middle - aged group （OG） ] gastric carcinoma （GC） patients. We analyzed the difference in demographic and clini- copathological characteristics between them. Results：There was a significantly higher proportion of females in the YG compared with the OG. The 5 - year overall survival of the YG was significantly lower compared to that of the OG. However, YG patients with curative resection had a similar 5 - year smwival rate to OG patients with curative resection. Female patients in the YG showed a significantly lower survival rate than males in the YG. Multivariate analyses revealed that macroscopic type, depth of invasion, peritoneal metastasis, distant metastasis and curative resection were independent prognostic factors for the YG with GC. Conclusion ： Early detection, early diagnosis, aggressive curative resection are the key to improve the level of youth gastric cancer treatment and prognosis, particularly in females.

关 键 词：胃癌 预后 年轻患者 

分 类 号：R735.2[医药卫生—肿瘤]