膜联蛋白A2在子宫内膜癌组织中的表达及临床意义  

The expression and clinical significance of annexin A2 in endometrial carcinoma

作　　者：高一平[1,2] 邓璐[1] 王慧敏[1] 蔡明博[1] 谭明子[1] 庄慧宇 李潇[1] 张嵩[1] 高嵩[1] 林蓓[1] 

机构地区：[1]中国医科大学附属盛京医院妇产科,辽宁沈阳110004 [2]天津市中心妇产科医院,天津300052

出　　处：《现代肿瘤医学》2016年第10期1608-1612,共5页Journal of Modern Oncology

基　　金：盛京自由研究者计划(编号:201303)

摘　　要：目的:检测膜联蛋白(annexin A2,ANXA2)在子宫内膜癌中的表达情况,探讨ANXA2表达与子宫内膜癌临床病理参数的关系及临床意义。方法:采用免疫组化SP法检测76例子宫内膜癌、27例非典型增生子宫内膜及16例正常子宫内膜中ANXA2的表达情况,并分析其与子宫内膜癌临床病理参数及预后的关系。结果:ANXA2在子宫内膜癌组(96.1%)和非典型增生组(96.3%)的阳性率明显高于正常子宫内膜组(62.5%)(P均<0.05)。ANXA2表达随着FIGO分期增加、分化程度减低而逐渐增加(P<0.05),ER、PR阴性组ANXA2阳性率(均为100.0%)明显高于阳性组(分别为87.5%,88.0%)(P均<0.05),而淋巴结转移阳性组ANXA2高表达率(93.8%)明显高于淋巴结转移阴性组(60.0%)(P<0.05)。ANXA2低表达组子宫内膜癌患者预后更佳(P<0.05)。结论:ANXA2在子宫内膜癌组织中的表达明显增高,ANXA2可监测子宫内膜癌患者预后。Objective： To explore the relationship between expression of annexin A2 （ANXA2） and clinicopathological parameters and the clinical significance of annexin A2 by detecting the expression of annexin A2 in different endometrial tissues. Methods：Expression of ANXA2 in 76 endometrial carcinoma,27 atypical hyperplasia endometriurn, 16 cases of normal endometrium was detected by immunohistochemistry, and the relationship between ANXA2 expression and clinicopathological parameters in endometrial carcinoma was analyzed. Results：The expression levels of ANXA2 in endometrial carcinoma and atypical hyperplasia （96.1% ,96.3% ） were significantly higher than normal endometrium （62.5%） （both P 〈 0.05）. ANXA2 expression was increased with FIGO stage progression and the decreasing of differentiation degree. The positive expression rates of ANXA2 in ER （ - ） and PR （ - ） group （ both were 100.0% ） were significantly higher than that of ER （ ＋ ） and PR （ ＋ ） groups （87.5% ,88.0% ,respectively, both P 〈0.05）. Strong expression rate of ANXA2 was significantly higher in lymph metastasis （ ＋ ） （93.8%） than in lymph metastasis （ - ） group （60.0%） （P 〈 0.05）. Higher ANXA2 expression level could predict a poor prognosis （P 〈 0.05 ）. Conclusion ： The expression level of ANXA2 was significantly increased in endometrial carcinoma and could predict poor prognosis of endometrial carcinoma patients.

关 键 词：子宫内膜癌 膜联蛋白A2 免疫组织化学 临床病理参数 

分 类 号：R737.33[医药卫生—肿瘤]