DUSP10和BZW1在卵巢浆液性肿瘤中的表达及临床意义  

Expression and clinical significance of DUSP10 and BZW1 in serous ovarian tumors

作　　者：岳娟[1] 刘菲[1] 姚丽[2] 王姝妹[2] 张伟[2] 李艳红 

机构地区：[1]第四军医大学唐都医院妇产科,陕西西安710038 [2]第四军医大学唐都医院病理科,陕西西安710038

出　　处：《现代肿瘤医学》2016年第10期1625-1630,共6页Journal of Modern Oncology

基　　金：卫生部医药卫生科技发展研究中心课题(编号:W2013FZ13);陕西省科学技术研究发展计划项目(编号:2014K11-01-01-25)

摘　　要：目的:检测双特异性磷酸酶10(dual specificity phosphatase 10,DUSP10)和碱性亮氨酸拉链蛋白BZW1抗体(basic leucine zipper and W2 domain containing protein 1,BZW1)分子在卵巢浆液性肿瘤中的表达情况,结合临床分期和病理分化结果,初步探讨它们在卵巢浆液性腺癌发生、发展中可能起到的作用。方法:采用免疫组化(En Vision法)检测卵巢上皮性肿瘤(良、恶性肿瘤)和人正常输卵管组织中DUSP10和BZW1分子的表达以及定位情况。结果:检测结果表明DUSP10和BZW1分子在人卵巢上皮性良、恶性肿瘤和人正常输卵管组织中均有表达,DUSP10在卵巢浆液性腺癌、卵巢浆液性腺瘤和正常输卵管组织中的阳性表达率分别为94.5%、86.9%和100%(P<0.01)。在卵巢浆液性腺癌中,DUSP10阳性表达率临床晚期高于早期(97.1%vs 92.1%,P<0.01);在高分化、中分化和低分化中的阳性率分别为100%、85.7%和96.9%(P<0.01)。而BZW1在这三种组织中的阳性表达率分别为57.5%、47.8%和77.7%(P<0.01)。在腺癌组织中,BZW1阳性表达率临床晚期低于早期(48.6%vs 65.8%,P<0.01);在高分化、中分化和低分化中的阳性率分别为47.4%、52.4%和66.7%(P<0.01)。结论:DUSP10在卵巢浆液性腺癌临床分期的早期阳性表达率低于晚期,表达差异显著,说明DUSP10在卵巢癌的发生过程中起到了一定作用;同样,BZW1在卵巢浆液性腺癌病理分级中的阳性表达率随着组织恶性程度的增加而增高,说明BZW1在卵巢浆液性腺癌中起到了类似癌基因的作用。Objective：To test the expression of dual specificity protein phosphatase 10 （DUSP10） and basic leucine zipper and W2 domain containing protein 1 （BZW1） molecules in serous ovarian tumors, and discuss their fucntions in the occurence and development of ovarian serous adenocarcinoma. Methods：Immunohistochemical analysis （EnVision method） was used to detect the expression of DUSP10 and BZW1 molecules in benign and malignant epithelial ovarian tumors and the normal fallopian tubes tissue. Results：DUSP10 and BZW1 molecules expressed in epi- thelial ovarian benign and malignant tumor and the normal fallopian tube. The positive expression rate of DUSP10 in serous ovarian adenocarcinoma, serous ovarian adenoma and the normal fallopian tube were 94.5% , 86.9% and 100% （P 〈 0.01 ）. In ovarian serous adenocarcinoma, the positive expression rate of DUSP10 in late stage was higher than that in early stage（97.1% vs 92.1% ,P 〈0.01 ）. The positive rates of DUSP10 in high differentiation,medium differentiation and low differentiation were 100% , 85.7% and 96.9% （ P 〈 0.01 ） , respectively. While the positive expression rates of BZW1 in the these three tissues were 57.5% ,47.8% and 77.7% （P 〈0.01 ）. In ovarian serous adenocarcinoma, the positive expression rate of BZW1 in late stage was lower than that in early stage（48.6% vs 65.8% ,P 〈0.01 ）The positive rates of BZW1 in high differentiation, medium differentiation and low differentiation were 47.4% ,52.4% and 6.7% （P 〈0.01 ）. Conclusion：DUSP10 may play an important role in carcinogenesis of serous ovarian cancer and BZWlmay function as an oncogene.

关 键 词：卵巢浆液性腺癌 DUSP10 BZW1 

分 类 号：R737.31[医药卫生—肿瘤]