气球状细胞痣的病理诊断及鉴别诊断  

Diagnosis and differential diagnosis of balloon cell nevus

作　　者：杨艳丽 刘斌 苏勤军 马迎春 马建武 

机构地区：[1]兰州军区总院病理科,甘肃兰州730050

出　　处：《现代肿瘤医学》2016年第10期1637-1639,共3页Journal of Modern Oncology

摘　　要：目的:探讨皮肤气球状细胞痣的病理诊断及鉴别诊断。方法:对1例皮肤气球状细胞痣应用免疫组化SP(streptavidin-perosidase)法观察,并进行临床病理分析。结果:皮肤组织真皮内见胞浆透亮的细胞排列成大小不等由胶原纤维分隔的小叶,痣细胞绝大部分为体积较大、胞质丰富且呈透明状或细颗粒状气球状痣细胞。胞核小而圆,大小一致,多位于细胞的中央,无异型性及核分裂像。免疫组化染色提示气球状细胞痣S-100(++)、Vimentin(++)、Melan-A(++)、Ki-67<5%,HMB-45仅在真皮浅层的灶性气球状细胞浆呈弱阳性表达。结论:气球状细胞痣极为罕见,需要与皮肤的多种透明细胞肿瘤进行鉴别,正确诊断主要依赖组织病理及免疫组化结果。Objective： To study the diagnosis and differential diagnosis of balloon cell nevus of the skin. Methods ： A patient with balloon cell nevus was observed to detect with a panel of streptavidin - perosidase immuno - histochemistry including S - 100, Vimentin, Ki - 67, HMB45. Results ： S - 100 （ ＋ ＋ ）, Vimentin （ ＋ ＋ ）, Melan - A （ ＋ ＋ ） , Ki -67 〈 5 % were determined. HMB -45 showed weak positive expression only balloon cell nevus cytoplasm in the superficial layer of dermis. Conclusion：Balloon cell nevus are rare. The diagnosis of balloon cell nevus depends on clinicopathology and immunohistochemical,which help to differential diagnosis with other many kinds of clear cell tumor.

关 键 词：气球状细胞痣 气球状细胞黑素瘤 S-100 MELAN-A HMB45 病理诊断及鉴别诊断 

分 类 号：R739.5[医药卫生—肿瘤]