放射对血脑屏障的影响及临床意义  

The effect of ionizing radiation on blood brain barrier and its clinical implication

作　　者：杨杉[1] 阎英[1] 孙颖[1] 杨志[1] 

机构地区：[1]辽宁中医药大学第一临床学院,辽宁沈阳110032

出　　处：《现代肿瘤医学》2016年第10期1645-1648,共4页Journal of Modern Oncology

基　　金：辽宁省科技攻关课题项目(编号:2012225008)

摘　　要：在脑部恶性肿瘤的治疗过程中,因为药物不能透过血脑屏障发挥作用,从而使脑部肿瘤的治疗方式局限化。电离辐射可引起血脑屏障的通透性增高,或为药物通过血脑屏障提供可能性。本文总结了放射导致血脑屏障通透性改变的分子机制、放射剂量对血脑屏障通透性的影响以及放疗联合药物治疗在脑部肿瘤治疗中的研究进展。Effective plasma concentration cannot be reached due to the existence of blood - brain barrier （BBB） in the treatment of brain neoplasm,which brings limits to therapeutic effects. The disruption of BBB induced by ionizing radiation may pave way for drug therapy which is often hampered by the presence of BBB. In this review, we summarized the molecular mechanism of BBB disruption,the influence of radiation dose on BBB and their application in the treatment of brain neoplasm.

关 键 词：脑肿瘤 放射疗法 血脑屏障 药物治疗 

分 类 号：R730.55[医药卫生—肿瘤]