炎症细胞因子在肿瘤微环境中的作用及其作为治疗靶点的研究进展  

Inflammatory cytokines as therapeutic targets in tumor immunotherapy

作　　者：马守宝[1] 林丹丹[1] 刘海燕[1] 

机构地区：[1]苏州大学生物医学研究院,苏州215123

出　　处：《生命科学》2016年第2期182-191,共10页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金面上项目(81273268;91029703;81471586)

摘　　要：肿瘤相关炎症是近年来肿瘤免疫领域的研究热点。炎症被称为恶性肿瘤的第八大生物学特征,其在肿瘤发生发展、侵袭转移过程中发挥重要作用。肿瘤微环境中存在大量的炎症细胞因子,如IL-1、IL-6、IL-12、IL-17、TNF-α和TGF-β,它们不仅可以募集炎症细胞到肿瘤部位,放大炎症效应,还可促进肿瘤细胞生长和转移,促进肿瘤血管、淋巴管生成。现主要从炎症细胞因子及肿瘤微环境入手,旨在探讨炎症细胞因子介导的慢性炎症在肿瘤发生发展过程中的重要作用,及其作为肿瘤治疗靶点的转化医学的研究进展及展望。Tumor-promoting inflammation, which is recognized as the eighth hallmark of cancer, is highly involved in the tumor growth, invasion and metastasis. Tumor microenvironment contains abundant inflammation cytokines, which contribute to multiple hallmark capabilities of the tumorigenesis by recruiting inflammatory cells to the tumor microenvironment, amplifying inflammation, promoting tumor proliferation, metastasis, angiogenesis and lymphangiogenesis. In this review, we will review recent advances in our understanding of the contribution of inflammatory cytokines to tumorigenesis, and discuss the potential applications of these cytokines as immunotherapeutic targets in cancer immunotherapy.

关 键 词：炎症 肿瘤 肿瘤微环境 细胞因子 治疗 

分 类 号：Q25[生物学—细胞生物学] R730.231[医药卫生—肿瘤]