替吉奥胶囊联合三维适型放射治疗老年贲门癌的疗效及安全性  

Safety and efficacy of S-1 combined with three-dimensional conformal radiotherapy in treating senile cardiac cancer

作　　者：黄亚妮[1] 王松林[1] 丁涛[1] 

机构地区：[1]湖北省钟祥市人民医院肿瘤科,钟祥431900

出　　处：《中国肿瘤临床与康复》2016年第3期293-296,共4页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨替吉奥胶囊联合三维适型放射治疗老年贲门癌的疗效及安全性。方法选取2010年5月至2014年10月间收治的79例老年贲门癌患者(≥55岁)为研究对象,根据患者意愿分为观察组(44例)和对照组(35例)。观察组患者采用常规治疗+三维适型放疗+替吉奥胶囊口服,对照组患者采用常规治疗+三维适型放疗。比较两组患者治疗前后胃蛋白酶原(PG)、癌胚抗原(CEA)及糖类抗原19-9(CA19-9)水平。治疗3个周期后,比较两组患者的客观缓解率。分析两组患者随访后的生存情况及不良反应发生率。结果两组患者治疗前PGⅠ、PGⅡ、CEA、CA19-9的差异均无统计学意义(P>0.05);治疗3个周期后,观察组患者PGⅠ及PGⅡ水平显著高于对照组(P<0.05),CEA及CA19-9水平显著低于对照组(P<0.05)。治疗3个周期后,观察组患者的客观缓解率明显高于对照组(72.7%和45.7%;2=15.200,P<0.05)。观察组患者的无进展生存期为(13.72±1.79)个月,总生存期为(20.30±4.16)个月,对照组分别为(8.53±0.67)个月和(19.23±1.68)个月。观察组患者的无进展生存期显著高于对照组,差异有统计学意义(P<0.05),两组患者总生存期的差异无统计学意义(P>0.05)。两组患者均有血液系统、消化系统、神经系统毒性反应及放射性损害,但均在可耐受范围内。两组患者不良反应发生率的差异无统计学意义(P<0.05)。结论替吉奥胶囊联合三维适型放疗在减少老年贲门癌患者CEA和CA19-9水平方面有一定作用,能够有效延长患者无进展生存期,疗效确切,值得临床推广应用。Objective To investigate the safety and efficacy of S-1 combined with three-dimensional conformal radiotherapy in treating senile cardiac cancer. Methods From May 2010 to October 2014,79 cases of senile cardiac cancer（ ≥ 55 years old） who received treatment in Zhongxiang People＇s Hospital were selected,according to the wishes of the patients,they were divided into observation group（ n = 44）and control group（ n = 35）. Patients in observation group received routine treatment ＋ three-dimensional conformal radiotherapy ＋ S-1 capsule. Patients in control group received routine treatment ＋ three-dimensional conformal radiotherapy. The levels of pepsinogen（ PG）,carcino-embryonic antigen（ CEA） and carbohydrate antigen 19-9（ CA19-9） were compared between the two groups before and after treatment. After 3cycles,the objective response rate of the two groups was compared. The survival and adverse reactions of the two groups were analyzed. Results The difference of CA19-9,CEA and PG before treatment in the two groups was not statistically significant（ P〈0. 05）. After 3 cycles of treatment,the levels of PG and PG in the observation group were significantly higher than those in the control group（ P〈0. 05）,CEA and CA19-9 levels were significantly lower than those in the control group（ P〈0. 05）. After 3 cycles of treatment,the objective response rate of the observation group was significantly higher than that in the control group（ 72. 7% vs 45. 7%,2= 15. 200,P〈0. 05）. Progression free survival（ PFS） in the observation group was（ 13. 72 ± 1. 79） months and overall survival was（ 20. 30 ± 4. 16） months,while in the control group were（ 8. 53 ± 0. 67） months and（ 19. 23 ± 1. 68） months respectively. The PFS of the observation group was significantly higher than that of the control group,with significant difference（ P〈0. 05）,but the total survival time of the two groups showed no significant difference（ P〈0. 05）. Two groups of patients occu

关 键 词：贲门肿瘤 替吉奥胶囊 三维适型放疗 有效性 安全性 

分 类 号：R735[医药卫生—肿瘤]