小细胞肺癌恶性程度与新辅助化疗预后的研究  

Malignant degree of small cell lung cancer and prognosis of neoadjuvant chemotherapy

作　　者：庞一雄[1] 黄维江[1] 胡磊[1] 郑威[1] 廖志敏[1] 胡琦[1] 

机构地区：[1]湖北省孝感市中心医院胸心外科,湖北孝感432000

出　　处：《海南医学院学报》2016年第9期898-901,共4页Journal of Hainan Medical University

基　　金：湖北自然科学基金(2012KFC143)~~

摘　　要：目的：分析新辅助化疗＋手术＋术后化疗对局限性小细胞肺癌恶性程度及预后情况的影响。方法：选取2010年11月~2015年2月间在湖北省孝感巿中心医院病理确诊并首治的局限性小细胞肺癌患者40例作为研究对象,随机分为观察组及对照组各20例。对照组患者接受手术＋术后化疗,观察组患者接受新辅助化疗＋手术＋术后化疗,对比两组患者的治疗后血清M2-PK、CYFRA21-1、CA125、NSE、TSGF水平,血清CEA、SCC、ProGRP水平,凋亡相关基因表达,侵袭转移相关指标表达水平差异。结果：观察组患者的治疗后血清中M2-PK、CYFRA21-1、CA125、NSE、TSGF水平值均低于对照组患者（P〈0.05）;观察组患者的治疗后血清CEA、SCC、ProGRP水平均低于对照组患者（P〈0.05）;观察组患者的治疗后p53、blc-2阳性表达率低于对照组患者,bax阳性表达率高于对照组患者（P〈0.05）;观察组患者的治疗后循环血中HIF-1α、STAT3、p-STAT3蛋白的阳性表达率均大幅低于对照组患者（P〈0.05）。结论：局限性小细胞肺癌患者接受新辅助化疗＋手术＋术后化疗,可以有效降低肿瘤恶性程度并抑制侵袭转移,有助于治疗预后的优化。Objective：To analyze the effect of neoadjuvant chemotherapy＋ surgery ＋ postoperative chemotherapy on the malignant degree and prognosis of limited small cell lung cancer.Methods：A total of 40 cases with limited small cell lung cancer pathologically diagnosed and first treated in our hospital from November 2010 to February 2015 were selected as research subjects and randomly divided into observation group and control group,each with 20 cases.Control group received surgery＋postoperative chemotherapy,observation group received neoadjuvant chemotherapy＋surgery＋ postoperative chemotherapy,and then differences in serum M2-PK,CYFRA21-1,CA125,NSE and TSGF levels,serum CEA,SCC and ProGRP levels,apoptosis-related gene expression as well as invasion and metastasis-related indicator expression of two groups after treatment were compared.Results：Serum M2-PK,CYFRA21-1,CA125,NSE and TSGF levels of observation group after treatment were lower than those of control group（P〈0.05）;serum CEA,SCC and ProGRP levels of observation group after treatment were lower than those of control group（P〈0.05）;p53and blc-2positive rates of observation group after treatment were lower than those of control group,and bax positive rate was higher than that of control group（P〈0.05）;positive rates of HIF-1α,STAT3 and p-STAT3 protein in circulating blood of observation group after treatment were significantly lower than those of control group（P〈0.05）.Conclusion：Neoadjuvant chemotherapy＋ surgery＋ postoperative chemotherapy for patients with limited small cell lung cancer can effectively reduce malignant degree of tumor,inhibit invasion and metastasis and help to optimize the prognosis.

关 键 词：局限性小细胞肺癌 新辅助化疗 恶性程度 预后 

分 类 号：R734.2[医药卫生—肿瘤]