联合检测血清CEA及外周血T淋巴细胞、DNT细胞在肺癌诊断中的应用  

Combined Detection of Serum CEA,Peripheral Blood T Lymphocyte and DNT Cells in the Diagnosis of Lung Cancer

作　　者：胡小倩[1] 周国芹[1] 王素霞[2] 曹明善 雷秋香[1] 滑天[4] 

机构地区：[1]河北医科大学附属邢台市人民医院检验科,河北邢台054001 [2]邢台医学高等专科学校第二附属医院,河北邢台054001 [3]邢台市第三医院,河北邢台054001 [4]河北医科大学附属邢台市人民医院妇科,河北邢台054001

出　　处：《标记免疫分析与临床》2016年第3期259-261,287,共4页Labeled Immunoassays and Clinical Medicine

基　　金：河北省邢台市科技局立项课题(编号:2015ZC084)

摘　　要：目的探讨肺部良、恶性病变鉴别的新方法。方法采用流式细胞仪测定肺癌患者、肺良性病变患者及健康体检者三组血清CEA及外周血T淋巴细胞亚群与DNT细胞的表达水平。结果联合检测血清CEA及外周血T淋巴细胞亚群与DNT细胞可将肺癌检出的灵敏度、特异度提高至90.8%、98.9%。结论利用血清CEA及外周血T淋巴细胞亚群与DNT细胞联合检测,将明显提高肺癌诊断的灵敏度和特异度,有较大的临床应用价值。Objective To investigate a new method for the identification of benign and malignant lesions of the lung. Methods The expression levels of CEA and T lymphocyte subsets and DNT cells in patients with lung cancer,benign lesions and healthy controls were measured by flow cytometry. Results The sensitivity and specificity of combined detection of CEA,T lymphocyte subsets and DNT cells were improved to 90. 8% and98. 9% respectively. Conclusion The combined detection of serum CEA,T lymphocyte subsets in peripheral blood and DNT cells could improve the sensitivity and specificity of diagnosis of lung cancer,and it has great clinical application value.

关 键 词：肺癌 血清CEA 外周血T淋巴细胞 DNT细胞 流式细胞术 

分 类 号：R734.2[医药卫生—肿瘤] R730.43[医药卫生—临床医学]