乌司他丁联合丙种球蛋白治疗急性化脓性腹膜炎的疗效观察  

Efficacy of ulinastatin combined with gamma globulin in treating patients with acute purulent peritonitis

作　　者：谢锦居 李志民[1] 王秀敏[2] 

机构地区：[1]厦门大学附属第一医院杏林分院普外科,福建厦门361022 [2]厦门大学医学院药学系,福建厦门361000

出　　处：《中国生化药物杂志》2016年第1期163-165,共3页Chinese Journal of Biochemical Pharmaceutics

基　　金：福建省科技计划项目(2011Y0051)

摘　　要：目的观察研究乌司他丁联合丙种球蛋白治疗急性化脓性腹膜炎的疗效分析。方法选取厦门大学附属第一医院杏林分院普外科2013年3月~2015年3月收治的确诊为急性化脓性腹膜炎的患者共70例,按随机数字表法分为观察组和对照组,每组各35例,对照组给予常规保守治疗,观察组给予乌司他丁联合丙种球蛋白治疗,治疗结束后,随访并记录2组患者相关指标的变化等情况。结果观察组患者治疗后内毒素含量为（626.9±130.5）pg/mL,低于对照组（867.4±124.2）pg/mL（P〈0.05）。观察组患者治疗后有效率高于对照组（97.14%vs.77.14%;χ~2=7.467,P〈0.05）。结论乌司他丁联合丙种球蛋白治疗急性化脓性腹膜炎的临床治疗效果确切,整体治疗效果优于常规治疗。Objective To observe the efficacy of ulinastatin combined with gamma globulin in treating patients with acute purulent peritonitis.Methods 70 cases diagnosed with acute purulent peritonitis from March 2013 to March 2015 were randomly divided into observation group and control group,35 cases in each group. The control group received conventional treatment and observation group received ulinastatin combined with gamma globulin treatment. The related indicators were followed up and recorded in two groups post-treatment. Results The endotoxin content post-treatment in observation group was lower than control group[（ 626. 9 ± 130. 5） vs.（ 867. 4 ± 124. 2） pg / mL,P〈0. 05]. The effective rate in observation group was higher than control group（ 97. 14% vs. 77. 14%; χ~2= 7. 467,P〈0. 05）. Conclusion Ulinastatin combined with gamma globulin has the exact efficacy in treating patients with acute purulent peritonitis whose efficacy is better than conventional treatment.

关 键 词：乌司他丁 丙种球蛋白 急性化脓性腹膜炎 

分 类 号：R576[医药卫生—消化系统]