脑缺血再灌注损伤的研究及药物治疗进展  

Advance in research of therapeutic medicines for cerebral ischemia-reperfusion injury

作　　者：王晓平[1,2] 倪京满[1] 

机构地区：[1]兰州大学药学院,兰州730000 [2]兰州大学第二医院,兰州730030

出　　处：《中国新药杂志》2016年第6期659-663,691,共6页Chinese Journal of New Drugs

基　　金：国家自然科学基金(81273440)

摘　　要：缺血性脑血管病(ischemic cerebrovascular disease,ICVD)是临床常见病,其发病率、致死率及致残率均较高。缺血后再灌注一方面可以挽救缺血半暗带内濒死的细胞,另一方面再灌注后各种原因使神经细胞损伤加重甚至死亡,导致缺血再灌注损伤。这个过程非常复杂,各种机制之间又密切联系,互为因果。现就其发生机制及药物治疗现状予以综述。Ischemic cerebrovascular disease（ ICVD） is one of the major diseases,and is a leading cause of high incidence,death and disability. Cerebral ischemia-reperfusion can restore blood reperfusion of ischemic tissue in time,but on the other hand it induces the damage and death of neuronal cells（ cerebral ischemia-reperfusion injury）. This process is very complicated,and there are a variety of factors and links involved. In this article,we summarized the advance in research of therapeutic medicines for cerebral ischemia-reperfusion injury.

关 键 词：脑缺血再灌注损伤 发生机制 药物治疗 

分 类 号：R743.3[医药卫生—神经病学与精神病学]