体检人群中尿酸与脂肪肝的相关性  

Association of uric acid with fatty liver disease in health examination subjects

作　　者：张娟[1] 王宏刚[1] 沈鹏[1] 王立珍[2] 黄晓丹[3] 季国忠[3] 杨晓钟[1] 

机构地区：[1]南京医科大学附属淮安第一医院消化内科,淮安223300 [2]南京医科大学第二附属医院体检中心 [3]南京医科大学第二附属医院消化医学中心

出　　处：《山西医科大学学报》2016年第3期211-214,共4页Journal of Shanxi Medical University

摘　　要：目的探讨体检人群中尿酸与脂肪肝的相关性。方法选取2011-01～2013-05在南京医科大学第二附属医院体检中心接受健康体检的32 428例体检者为研究对象,测量身高、体重、血压,检查血常规、血生化以及腹部B超,应用统计学软件对患者进行分组分析。结果脂肪肝检出率为38.4%（12 448/32 428）,高尿酸血症检出率为11.3%（3 666/32 428）。脂肪肝组人群的年龄、体质量指数、收缩压、舒张压、空腹血糖、总胆固醇、甘油三酯、低密度脂蛋白-胆固醇（LDL-C）、谷丙转氨酶、谷草转氨酶、γ-谷氨酰转肽酶、总胆红素、白蛋白、尿素氮、肌酐和尿酸均显著高于非脂肪肝组。同样,高尿酸组人群的这些代谢相关指标高于正常尿酸组,且高尿酸患者脂肪肝患病率为57.9%（2 122/3 666）,高于正常尿酸组（35.9%,10 326/28 762）。进一步应用Logistic回归分析发现高尿酸血症患者脂肪肝的患病风险增加至2.454倍（OR=2.454,95%CI 2.288-2.631）,经多因素校正后患病风险仍有1.47倍（OR=1.470,95%CI 1.345-1.606）,差异有统计学意义（P〈0.05）。结论高尿酸血症可能是脂肪肝患病的一个独立危险因素。Objective To explore the correlation between uric acid and fatty liver disease（ FLD） in health examination subjects.Methods A total of 32 428 subjects undergoing health check-up in the Second Affiliated Hospital of Nanjing Medical University from January 2011 to May 2013 were enrolled in this study. Height,weight and blood pressure were measured,and routine blood examination,biochemical examination and abdominal ultrasound were performed. Results The overall prevalence of FLD diagnosed by ultrasonography was 38. 4%（ 12 448 /32 428） and the prevalence of hyperuricemia was 11. 3%（ 3 666 /32 428）. The age,body mass index,systolic blood pressure,diastolic blood pressure,fasting glucose,total cholesterol,triglycerides,low-density lipoprotein-cholesterol（ LDL-C）,alanine aminotransferase（ ALT）,aspartate aminotransferase（ AST）,γ-glutamyl transferase（ GGT）,total bilirubin,albumin,blood urea nitrogen,creatinine and uric acid were significantly higher in FLD group than in non-FLD group. Similarly,these metabolism-related indicators in patients with hyperuricemia were higher than that in patients with normal uric acid. In addition,the prevalence of FLD in hyperuricemia patients was 57. 9%（ 2 122 /3 666）,higher than that in patients with normal uric acid（ 35. 9%,10 326 /28 762）. Logistic regression analysis revealed that hyperuricemia was positively associated with FLD（ OR = 2. 454,95% CI2. 288- 2. 631,P〈0. 05）. After adjusting for possible factors associated with FLD,multivariate regression analysis showed that the association between hyperuricemia and FLD was also statistically significant（ OR = 1. 470,95% CI 1. 345- 1. 606,P〈0. 05）. Con-clusion The results suggest hyperuricemia may be an independent risk factor for FLD.

关 键 词：高尿酸血症 脂肪肝 危险因素 

分 类 号：R575[医药卫生—消化系统]