双相障碍抑郁相患者静息态脑功能磁共振局部一致性的研究  

Altered Regional Homogeneity in Bipolar Depression:A Resting-state Functional Magnetic Resonance Imaging Study

作　　者：姜晓薇[1] 周千[2] 汤艳清[2] 王菲[2] 

机构地区：[1]中国医科大学附属第一医院放射科脑功能研究室,沈阳110001 [2]中国医科大学附属第一医院精神医学科,沈阳110001

出　　处：《中国医科大学学报》2016年第4期305-308,共4页Journal of China Medical University

基　　金：国家自然科学基金(81271499)

摘　　要：目的对处于抑郁相的双相障碍患者静息态脑功能的异常变化进行研究,探求双相障碍患者抑郁相的病理生理机制。方法利用静息态功能磁共振局部一致性(ReHo)方法,比较24例处于抑郁相的双相障碍患者和28例健康对照的大脑静息态功能磁共振数据。结果处于抑郁相的双相障碍患者双侧额上回、双侧额中回、双侧内侧前额叶、双侧补充运动区、左侧中央旁小叶及左侧中央前回的ReHo值高于健康对照组,且差异有统计学意义(P<0.001)。结论处于抑郁相的双相障碍患者双侧额上回、双侧额中回、双侧内侧前额叶、双侧补充运动区、左侧中央旁小叶及左侧中央前回的脑功能存在异常,这些脑区的异常功能可能与双相障碍抑郁相的病理生理机制有关。Objective To study the abnormal alteration of regions in bipolar depression patients, so as to investigate its pathophysiologie mecha- nism. Methods Regional homogeneity （ReHo） technology of resting-state functional magnetic resonance imaging were used to compare 24 bipolar depression patients and 28 healthy controls. Results Compared to the healthy controls, the bipolar depression patients exhibited significantly higher ReHo value in the bilateral superior frontal gyms, the bilateral middle frontal gyrus, the bilateral medial frontal cortex, the bilateral supplementary motor area, the left paracentral lobule and the left precentral gyras （all P 〈 0.001 ）. Conclusion The abnormal function in the bilateral superior frontal gyrus, the bilateral middle frontal gyrus, the bilateral medial frontal cortex, the bilateral supplementary motor area, the left pamcentral lobule and the left preeentral gyrus may associate with the mechanism of pathophysiology in bipolar depression.

关 键 词：双相障碍 抑郁相 静息状态 功能磁共振 局部一致性 

分 类 号：R749.4[医药卫生—神经病学与精神病学]