TRIM24在膀胱尿路上皮癌中的表达及意义  

Expression and Significance of TRIM24 in Uroepithelium Cell Carcinoma of Bladder

作　　者：张秀伟[1] 徐慧慧[1] 薛东炜[2] 

机构地区：[1]中国医科大学附属第四医院病理科,沈阳110032 [2]中国医科大学附属第四医院泌尿外科,沈阳110032

出　　处：《中国医科大学学报》2016年第4期365-367,共3页Journal of China Medical University

摘　　要：目的检测转录调节因子1α(TRIM24)在膀胱尿路上皮癌中的表达及其与临床病理因素间的关系。方法应用免疫组化方法检测膀胱尿路上皮癌中TRIM24的蛋白表达情况。结果 TRIM24在41.7%(30/72)的膀胱尿路上皮癌中阳性表达,且其过表达与肿瘤T分期(P=0.029)和分化(P=0.043)相关。结论 TRIM24在膀胱尿路上皮癌中过表达,且其过表达与肿瘤分期、分化相关,可能成为治疗人类膀胱尿路上皮癌的候选靶基因。Objective To detect the expression of TRIM24 in uroepithelium cell carcinoma of bladder （BUCC） and analyze the relationship be- tween its expression and clinical pathological factors. Methods Immunohistochemical methods were employed to evaluate protein level of TRIM24 in BUCC. Results TRIM24 expression was observed in the nuclear compartments of tumor cells, while normal epithelia of bladder tissues exhibited negative results. For 72 BUCC tissues, TRIM24 overexpression （ score ≥ 4） was observed in 41.6% of cases （30/72）. TRIM24 expression correlat- ed with invasive depth （P = 0.029） and patients with high TRIM24 expression had high grade of BUCC （P = 0.043 ）. Conclusion There was sig- nificant over expression of TRIM24 in BUCC, which was correlated with poor differentiation and high grade of BUCC. It may become a candidate tar- get gene for the treatment of human uroepithelium cell carcinoma of bladder.

关 键 词：转录调节因子1α 膀胱尿路上皮癌 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]