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作 者:王知俊[1] 郑凌艳[1] 浦益萍[1] 谢李松[1] 石欢[1] 俞创奇[1]
机构地区:[1]上海交通大学医学院附属第九人民医院·口腔医学院口腔外科,上海市口腔医学重点实验室,上海200011
出 处:《中国口腔颌面外科杂志》2016年第2期128-133,共6页China Journal of Oral and Maxillofacial Surgery
基 金:国家自然科学基金(81100766)
摘 要:目的:分析IgG4相关唾液腺炎和有"唾液腺肿大"类似表现的常见唾液腺非肿瘤疾病的特点,明确其临床鉴别诊断要点。方法:回顾分析诊断为IgG4相关唾液腺炎患者的临床资料,与有腺体肿大类似表现的唾液腺非肿瘤疾病进行比较,重点从病史及临床表现、血液免疫学和组织病理学方面比较IgG4相关唾液腺炎与舍格伦综合征(Sjogren’ssyndrome,SS)的差异,应用SAS8.0软件包对数据进行非参数统计。结果:335例唾液腺非肿瘤疾病患者纳入本研究,包括IgG4相关唾液腺炎25例、阻塞性唾液腺炎279例和SS31例。比较IgG4相关唾液腺炎与阻塞性唾液腺炎和SS的疾病特点可见,其在病史及临床检查、血液免疫学和组织病理学等方面均有各自特点,差异显著。结论:IgG4相关唾液腺炎是一类以唾液腺肿大为典型表现的唾液腺慢性炎症,临床上应综合多方面考虑,与其他可能引起唾液腺肿大症状的疾病明确鉴别,准确诊断,为进一步制订合理的治疗方案提供依据。PURPOSE: To discuss the clinical features of Ig G4-related sclerosing sialadenitis and salivary glands nonneoplastic diseases presenting gland swelling, to make clear the key points of clinical differential diagnosis. METHODS:We retrospectively analyzed and compared the clinical data of Ig G4-related sclerosing sialadenitis with those of salivary glands non-neoplastic diseases especially Sjogren's syndrome(SS) in medical history, clinical examination, serology and pathology. The statistical analysis was performed using SAS 8.0 software package. RESULTS: Three hundred and thirtyfive patients with salivary glands non-neoplastic diseases were included in the study, including 25 Ig G4-related sclerosing sialadenitis, 279 obstructive sialadenitis and 31 SS. We compared Ig G4-related sclerosing sialadenitis with the others and found out significant differences in each aspects. CONCLUSIONS: Ig G4-related sclerosing sialadenitis is a kind of chronic salivary gland inflammation with glands swelling. In order to make a definite diagnosis with other salivary glands non-neoplastic diseases, a comprehensive analysis is needed.
关 键 词:IgG4相关唾液腺炎 阻塞性唾液腺炎 舍格伦综合征 鉴别诊断
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