X-连锁凋亡抑制蛋白基因与卵巢癌化疗药物耐药关系的研究进展  

Research progress of relationship between X-linked inhibitor of apoptosis protein gene and chemoresistance in ovary cancer

作　　者：陈晨[1] 李冉红[1] 刘辉[1] 

机构地区：[1]四川大学华西第二医院妇产科,成都610041

出　　处：《中华妇幼临床医学杂志（电子版）》2016年第1期104-107,共4页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：四川省科技厅课题(0040215301546)~~

摘　　要：X-连锁凋亡抑制蛋白(XIAP)目前被认为是作用最强的内源性凋亡抑制蛋白(IAP),陆续有研究结果发现,XIAP基因与卵巢癌化疗药物耐药密切相关,这对于卵巢癌的化疗具有重要的研究意义。笔者拟就于细胞生物学角度从细胞凋亡着手介绍XIAP的结构、生物学功能、调节,以及目前XIAP基因与卵巢癌化疗药物耐药相关关系的研究进展及其临床价值进行综述。X-1inked inhibitor of apoptosis protein（XIAP）,currently considered as the most potent endogenous inhibitor of apoptosis protein（IAP）.More and more literatures indicate that XIAP gene has a close relationship with chemoresistance in ovarian cancer,which also lays great significance in the treatment of ovarian cancer.This review intends to give a comprehensive introduction of XIAP′s structure,biological function,regulation,and introduces the current research progress of the relationship between XIAPgene and chemoresistance in ovarian cancer,as well as its clinical value.

关 键 词：X连锁凋亡抑制蛋白质 卵巢肿瘤 抗药性 肿瘤 RNA 小分子干扰 妇女 

分 类 号：R737.31[医药卫生—肿瘤]