CD44V6和Bcl-2在眼睑部基底细胞癌中的表达及意义  

The expressions and significance of CD44V6 and Bcl-2 in eyelid basal cell carcinoma

作　　者：李文捷[1] 张煦[2] 酒旭东[1] 

机构地区：[1]兰州大学第一医院眼科,甘肃兰州730000 [2]兰州大学基础医学院病理研究所,甘肃兰州730000

出　　处：《中国临床研究》2016年第3期298-300,共3页Chinese Journal of Clinical Research

摘　　要：目的探讨CD44V6和Bcl-2蛋白在眼睑部基底细胞癌中的表达及意义。方法选取眼科2000年至2010年手术切除眼睑部基底细胞癌的标本共52例。利用SP免疫组化法检测眼睑部基底细胞癌组织中CD44V6和Bcl-2蛋白的表达。随访5年,观察复发情况。结果 CD44V6蛋白的阳性表达率在眼睑部基底细胞癌分化型(0)与未分化型(35.7%)比较以及复发者(57.1%)和未复发者(2.2%)比较,差异有统计学意义(P均<0.01)。Bcl-2蛋白的阳性表达率在分化型(94.7%)与未分化型(85.7%)比较差异无统计学意义(P>0.05);在复发者(57.1%)和未复发者(97.8%)比较差异有统计学意义(P<0.01)。结论眼睑部基底细胞癌未分化组CD44V6阳性率较高,未复发组Bcl-2阳性率较高;CD44V6和Bcl-2可能参与了眼睑部基底细胞癌的发生发展过程。Objective To investigate the expressions and significance of CD44V6 and Bcl-2 in eyelid basal cell carcinoma（ EBCC）. Methods The surgical samples of 52 EBCC patients treated in the first hospital of lanzhou university from 2000 to 2010 were collected and divided into differentiated group and undifferentiated group according to differentiation degree of tumor cells. The expressions of CD44V6 and Bcl-2 proteins in carcinoma tissues were detected by immunohistochemical SP method. All patients were followed up for 5 years and surveyed for relapse status. Results There were significant differences in positive expression rates of CD44V6 protein between EBCC tissues of type differentiation and type undifferentiation（ 0 vs 35. 7%,P 〈0. 01） and between patients of recurrence and non-recurrence（ 57. 1% vs 2. 2%,P 〈0. 01）. There was no significant difference in positive expression rates of Bcl-2 protein between EBCC tissues of type differentiation and type undifferentiation（ 94. 7% vs 85. 7%,P 〈0. 05）,while there was significant difference in its expression rates between patients of recurrence and non-recurrence（ 57. 1% vs 97. 8%,P 〈0. 01）. Conclusion The higher positive expression rates of CD44V6 and Bcl-2 were respectively seen in EBCC tissues of type undifferentiation and the patients of non-recurrence.It is suggested that CD44V6 and Bcl-2 may be involved in the occurrence and development process of eyelid basal cell carcinoma.

关 键 词：基底细胞癌 眼睑部 CD44V6基因 BCL-2基因 免疫组化 

分 类 号：R739.71[医药卫生—肿瘤]